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CTNNB1 — MET

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: CTNNB1 → MET (increases, CTNNB1 Activity)
  Evidence: Page 54 - "HGF/SF stimulation promotes the tyrosine phosphorylation of b-catenin, interfering with the ability of b-catenin to bind the intracellular portion of E-cadherin (Figure 6). The result is a dismantling of cell-cell adhesion complexes (105)."
• KEGG Adherens junction: MET → CTNNB1 (protein-protein, inhibition)
• NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly: HGF(dimer)/MET(dimer) complex (MET) → E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1) (modification, activates)
  Brembeck et al., Genes Dev 2004
  Evidence: mutant phenotype, other species
• NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly: HGF(dimer)/MET(dimer) complex (MET) → E-cadherin/beta catenin/alpha catenin complex (CDH1-CTNNB1-CTNNA1) (translocation, collaborate)
  Kimura et al., J Biol Chem 2006
  Evidence: mutant phenotype
• NCI Pathway Database Posttranslational regulation of adherens junction stability and dissassembly: N-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH2-CTNNB1-CTNNA1-CTNND1) → HGF(dimer)/MET(dimer) complex (MET) (modification, collaborate)
  David et al., J Cell Sci 2008
  Evidence: assay, physical interaction
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): beta catenin (CTNNB1) → MET/beta catenin complex (MET-CTNNB1) (modification, collaborate)
  Monga et al., Cancer Res 2002*, Zeng et al., Exp Cell Res 2006*
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): beta catenin (CTNNB1) → HGF(dimer)/MET(dimer) complex (MET-HGF) (modification, collaborate)
  Monga et al., Cancer Res 2002*, Zeng et al., Exp Cell Res 2006*
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): HGF complex (HGF) → MET/beta catenin complex (MET-CTNNB1) (modification, collaborate)
  Monga et al., Cancer Res 2002*, Zeng et al., Exp Cell Res 2006*
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met): MET/beta catenin complex (MET-CTNNB1) → HGF(dimer)/MET(dimer) complex (MET-HGF) (modification, collaborate)
  Monga et al., Cancer Res 2002*, Zeng et al., Exp Cell Res 2006*
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Stabilization and expansion of the E-cadherin adherens junction: MET (MET) → E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1) (modification, collaborate)
  Qian et al., EMBO J 2004
  Evidence: assay
• NCI Pathway Database Stabilization and expansion of the E-cadherin adherens junction: E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin complex (CDH1-CTNNB1-CTNNA1-CTNND1) → HGF/MET complex (HGF-MET) (modification, inhibits) Qian et al., EMBO J 2004
  Evidence: assay

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: CTNNB1 — MET (physical association, affinity chromatography technology) Davies et al., Int J Mol Med 2001*
• IRef Hprd Interaction: CTNNB1 — MET (in vivo) Monga et al., Cancer Res 2002*
• IRef Innatedb Interaction: CTNNB1 — MET (unknown, -) Matteucci et al., Cell Mol Life Sci 2006*
• IRef Intact Interaction: Complex of 59 proteins (association, tandem affinity purification) Li et al., Molecular systems biology 2013

Text-mined interactions from Literome

Danilkovitch-Miagkova et al., Mol Cell Biol 2001 (Cell Transformation, Neoplastic) : Activation of beta-catenin by oncogenic RON and MET constitutes a new pathway, which might lead to cell transformation by these and other mutant growth factor RTKs
Herynk et al., Clin Exp Metastasis 2003 (Colorectal Neoplasms) : Activation of c-Met in colorectal carcinoma cells leads to constitutive association of tyrosine phosphorylated beta-catenin
Pai et al., FASEB J 2003 (Colonic Neoplasms...) : Here we provide evidence that PGE2 transactivates c-Met-R ( contingent upon functional EGFR ), increases tyrosine phosphorylation and nuclear accumulation of beta-catenin , and induces urokinase-type plasminogen activator receptor ( uPAR ) mRNA expression
Fischer et al., J Biol Chem 2004 (Carcinoma...) : Interestingly, stimulation of the Met receptor by either GPCR agonists, EGF or its cognate ligand HGF, resulted in release of Met associated beta-catenin and in its Met dependent translocation into the nucleus, as analyzed by small interfering RNA mediated knockdown of the Met receptor