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MAPK13 — PTEN
Text-mined interactions from Literome
Nakashima et al., J Biol Chem 2000
(MAP Kinase Signaling System) :
Further, insulin induced phosphorylation of downstream targets Akt and p70S6 kinase were also inhibited significantly by overexpression of
PTEN , whereas tyrosine phosphorylation of the insulin receptor and IRS-1 or the phosphorylation of
mitogen activated protein kinase were not
affected , suggesting that the Ras/mitogen activated protein kinase pathway remains fully functional
Weng et al., Hum Mol Genet 2001
(Breast Neoplasms) :
PTEN inhibits insulin stimulated
MEK/MAPK activation and cell growth by blocking IRS-1 phosphorylation and IRS-1/Grb-2/Sos complex formation in a breast cancer model
Aikawa et al., Hypertension 2002
:
Overexpression of the tumor suppressor
PTEN , which inhibits outside-in integrin signaling, strongly
suppressed stretch induced activation of p38
MAPK
Waite et al., Hum Mol Genet 2005
:
Active
PTEN results in decreased phosphorylation of Akt and
MAPK , the up-regulation of p27 and down-regulation of cyclin D1 protein levels resulting in decreased proliferation and an increase in apoptosis
Chung et al., Cancer Res 2005
(Breast Neoplasms...) :
We found that cytoplasmic PTEN down-regulates phosphorylation of Akt and up-regulates p27 ( kip1 ), whereas nuclear
PTEN down-regulates cyclin D1 and
prevents the phosphorylation of
MAPK
Chandrasekar et al., Biochem Biophys Res Commun 2006
:
IL-18 induced activation of NF-kappaB and
PTEN upregulation were
mediated by
p38MAPK
Furumoto et al., J Immunol 2006
:
Loss of
PTEN caused constitutive phosphorylation of Akt, p38
MAPK , and JNK, as well as cytokine production and enhancement in cell survival, but not degranulation
Chung et al., Hum Mol Genet 2006
:
Utilizing MCF-7 Tet-Off breast cancer cell lines stably expressing two different nuclear localization defective PTEN mutants, as well as wild-type PTEN and empty vector control cells, we demonstrate that nuclear
PTEN down-regulates cyclin D1 transcription and this event is
mediated by the down-regulation of
MAPK specifically by nuclear localized PTEN
Amorim et al., J Neurosci Res 2010
:
These findings suggest that the regulation of the phosphorylation of PP2A and
PTEN may be
involved in the effects of progesterone on the phosphorylation of Tau and on the activity of phophoinositide-3 kinase and
mitogen activated protein kinase in the brain
Ciuffreda et al., J Mol Med (Berl) 2012
(Disease Models, Animal...) :
The
mitogen activated protein kinase ( MAPK ) cascade
controls phosphatase and tensin homolog (PTEN) expression through multiple mechanisms
Nakdimon et al., PLoS Genet 2012
(Neoplasms) :
PTEN negatively
regulates MAPK signaling during Caenorhabditis elegans vulval development
Masliah-Planchon et al., BMC genomics 2013
(Neurofibroma, Plexiform...) :
In MPNSTs, significant deregulated miRNAs were involved in
PTEN repression ( miR-301a, miR-19a, and miR-106b ),
RAS-MAPK pathway
regulation ( Let-7b, miR-195, and miR-10b ), mesenchymal transition ( miR-200c, let-7b, miR-135a, miR-135b, and miR-9 ), HOX genes expression ( miR-210, miR-196b, miR-10a, miR-10b, and miR-9 ), and cell cycle progression ( miR-195, let-7b, miR-20a, miR-210, miR-129-3p, miR-449a, and miR-106b )