Fazeli et al., Mutagenesis 2012
(Calcium Signaling) :
In summary, in kidney cells the DNA damaging activity of Ang II depends on an AT1R mediated activation of NADPH oxidase via PLC , PKC and calcium signalling, with the NADPH subunit Nox4 playing a crucial role
Goldman et al., Biochem Biophys Res Commun 1994
:
PtdIns-PLC activation was suppressed by down regulation or inhibition of PKC, by inhibition of NADPH oxidase activity and scavenging of its product, and by inhibitors of protein tyrosine kinase activity