Ernfors et al., Trends Neurosci 2003
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A recent study using mice carrying a mutation in a specific tyrosine residue of trkB pinpoints a necessary role for the phospholipase-Cgamma ( PLCgamma ) pathway in CREB activation and LTP maintenance
Iwamoto et al., Cytotechnology 2005
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PLCgamma2 Activates CREB dependent Transcription in PC12 Cells Through Phosphorylation of CREB at Serine 133 ... siRNA mediated reduction of the expression of PLCgamma2 , but not PLCgamma1, inhibited both the phosphorylation of CREB at S133 and the activation of CREB dependent transcription following treatment of cells with forskolin or ionomycin, which increases the intracellular concentrations of cAMP or Ca ( 2+ ), respectively