Arthur et al., J Cell Biol 2004
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Overexpressed VAV2 and Tiam1 specifically require Rap1 to promote spreading, even though Rac1 is activated independently of Rap1
Birukova et al., Mol Biol Cell 2013
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This mechanism also included Rap1 dependent membrane translocation of the Rac1-specific GEF Tiam1 and activation of Rac1 dependent peripheral cytoskeletal dynamics, leading to resealing of intercellular gaps