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MAPK14 — PPARGC1A

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: PPARGC1A → MAPK14 (directlyIncreases, PPARGC1A Activity) Puigserver et al., Mol Cell 2001*
  Evidence: PhosphoElm data from PMID 15212693
• NCI Pathway Database Signaling mediated by p38-alpha and p38-beta: p38alpha-beta-active (MAPK14/MAPK11) → PGC1 (PPARGC1A) (modification, activates) Puigserver et al., Mol Cell 2001*
  Evidence: mutant phenotype, assay, reporter gene
• Reactome Reaction: PPARGC1A → MAPK14 (reaction) Blanco-Aparicio et al., J Cell Biol 1999*, Knutti et al., Proc Natl Acad Sci U S A 2001*, Wright et al., J Biol Chem 2007*, Gibala et al., J Appl Physiol 2009*, Little et al., Am J Physiol Regul Integr Comp Physiol 2011*, Jiang et al., J Biol Chem 1997*

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: MAPK14 — PPARGC1A (in vitro) Puigserver et al., Mol Cell 2001*
• IRef Hprd Interaction: MAPK14 — PPARGC1A (in vivo) Puigserver et al., Mol Cell 2001*
• STRING interaction: PPARGC1A — MAPK14 (interaction, mapped from kegg_pathways)
• STRING interaction: PPARGC1A — MAPK14 (interaction, mapped from kegg_pathways)
• STRING interaction: MAPK14 — PPARGC1A (interaction, mapped from kegg_pathways)
• STRING interaction: MAPK14 — PPARGC1A (interaction, mapped from kegg_pathways)

Text-mined interactions from Literome

Rasbach et al., J Biol Chem 2007 (Reperfusion Injury) : Additional inhibitor studies revealed that the sequential activation of Src, p38 MAPK, EGFR, and p38 MAPK regulate the expression of PGC-1alpha following oxidant injury
Luo et al., J Mol Neurosci 2009 (Reperfusion Injury) : At the same time, PD98059 ( ERK MAPK inhibitor ) and SB203580 ( P38 MAPK inhibitor ) also prevented the up-regulation of PGC-1alpha in OGD neurons and MK801 can inhibit the expression of P38 and ERK MAPK