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AKT2 — TIE1

Text-mined interactions from Literome

Kontos et al., Mol Cell Biol 2002 : The endothelial receptor tyrosine kinase Tie1 activates phosphatidylinositol 3-kinase and Akt to inhibit apoptosis ... Ligand stimulation of fTie1 resulted in Tie1 autophosphorylation and downstream activation of PI 3-kinase and Akt
Morris et al., J Mol Med (Berl) 2005 : Dominant negative Akt inhibited the pro-survival activity of mutant Tie2 ... These data suggest that a primary effect of R849W Tie2 in VM is to allow survival of mural cell poor vessels via ligand independent Tie2 activation of Akt and endothelial survival, rather than to directly induce formation of dysmorphogenic vessels
Tai et al., J Biol Chem 2005 : Tie2 and PECAM1 expression decreased > 80 % after siRNA treatment, and flow stimulated phosphorylation of ERK1/2, Akt , and endothelial nitric oxide synthase was significantly inhibited by Tie2 and PECAM1 siRNA
Yuan et al., FASEB J 2007 : Ang1 mediated AKT and 42/44MAPK phosphorylation is predominantly Tie2 mediated , and Tie1 down-regulates this pathway
Fukuhara et al., Nat Cell Biol 2008 : Furthermore, Tie2 activated at cell-cell or cell-substratum contacts leads to preferential activation of Akt and Erk, respectively
Thomas et al., J Biol Chem 2010 : However, only Ang-1 induces Tie2 dependent Akt activation and subsequent survival signaling and endothelial quiescence