Mahimainathan et al., J Biol Chem 2009
(Angiomyolipoma...) :
TSC2 deficiency increases PTEN via HIF1alpha
Zhou et al., Hum Mol Genet 2009
(Disease Models, Animal...) :
Interestingly, disruption of Pten , an upstream regulator of TSC1/TSC2 , in the same cells, does not lead to PKD seemingly due to limited activation of mTORC1, suggesting that PTEN may not be a major upstream regulator of TSC/mTORC1 during early postnatal kidney development