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PPARG — PTEN
Text-mined interactions from Literome
Patel et al., Curr Biol 2001
:
Here, we show that the activation of
PPARgamma by its selective ligand, rosiglitazone,
upregulates PTEN expression in human macrophages, Caco2 colorectal cancer cells, and MCF7 breast cancer cells ... Antisense mediated disruption of
PPARgamma expression
prevented the upregulation of
PTEN that normally accompanies monocyte differentiation and reduced the proportion of macrophages undergoing apoptosis, while electrophoretic mobility shift assays showed that PPARgamma is able to bind two response elements in the genomic sequence upstream of PTEN
Goetze et al., Hypertension 2002
:
The inhibition of Akt-phosphorylation was accompanied by a
PPARgamma-ligand mediated upregulation of
PTEN , a phosphatase that functions as a negative regulator of PI3K -- > Akt signaling
Farrow et al., Biochem Biophys Res Commun 2003
(Pancreatic Neoplasms) :
The purpose of this study was to examine whether activation of
PPARgamma can
increase the expression of the tumor suppressor
PTEN and inhibit PI3K activity
Hong et al., Biochem Biophys Res Commun 2003
:
We also show that the observed effects are independent of
PPAR gamma mediated regulation of the lipid phosphatase
PTEN
Lee et al., Lung Cancer 2006
(Carcinoma, Non-Small-Cell Lung...) :
This study investigated the
effects of
PPAR-gamma agonist ( rosiglitazone ) on the expression of
PTEN , as well as EGFR tyrosine kinase inhibitor ( gefitinib ) 's antitumor activity in A549 cells
Teresi et al., Int J Cancer 2006
(Breast Neoplasms...) :
Increased
PTEN expression
due to transcriptional activation of
PPARgamma by Lovastatin and Rosiglitazone ... A putative PPARgamma binding site in the PTEN promoter indicates that
PPARgamma may
regulate PTEN expression
Teresi et al., PPAR research 2008
:
Recent in vitro studies have shown that
PPARgamma can
regulate the transcription of
phosphatase and tensin homolog on chromosometen ( PTEN ), a known tumor suppressor