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EGR1 — PRL
Text-mined interactions from Literome
Goldhar et al., Mol Cell Endocrinol 2005
:
Deletion and mutation analysis identified a GC-rich region in the proximal region of the VEGF promoter that constitutively bound Sp1 and
PRL induced
Egr-1 ... Our results indicate that
PRL induces VEGF expression through
Egr-1 , and implicates VEGF as an intermediary of PRL regulated angiogenesis
Blume et al., Brain Res 2009
(MAP Kinase Signaling System) :
Prolactin induces
Egr-1 gene expression in cultured hypothalamic cells and in the rat hypothalamus ... To identify mechanisms by which PRL induces neuroplasticity, we studied the ability of
PRL to
induce the transcription factor
Egr-1 in the hypothalamic cell line, 4B, in vitro, and in specific neuronal cell types of the hypothalamus in vivo ...
PRL induced
Egr-1 mRNA expression in 4B cells, an effect which was prevented by the MEK inhibitor, U0126 ... In vivo, intracerebroventricular
PRL ( 1 microg )
increased Egr-1 mRNA levels in the hypothalamic paraventricular ( PVN ) and supraoptic nuclei (SON) of female rats