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HSPG2 — TNF
Text-mined interactions from Literome
Heyninck et al., Anticancer Res 1999
(Fibrosarcoma...) :
The reduced TNF-sensitivity of A20 expressing L929 cells was correlated with a decrease of
TNF induced phospholipase A2 (PLA2),
phospholipase C (PLC) and phospholipase D ( PLD ) activation
Ishibashi et al., Eur J Pharmacol 2006
(Carcinoma...) :
100 mug/ml of carbocisteine was able to inhibit the
TNF-alpha induced expression of hST3GallV mRNA, FUT3 mRNA, C2/4GnT mRNA and sialyl-Lewis x epitopes as well as the TNF-alpha induced activity of
PI-PLC in NCI-H292 cells
Liu et al., Am J Respir Cell Mol Biol 2007
:
In this study we investigated the
role of phosphatidylcholine-specific phospholipase C (
PC-PLC ) in silica stimulated induction of
TNF-alpha and IL-1beta and how PC-PLC activity is regulated by silica in a rat alveolar macrophage model ... We demonstrated that inhibition of
PC-PLC , which was achieved with tricychodecan-9-yl-xanthate ( D609 ),
blocked the silica stimulated induction of
TNF-alpha and IL-1beta in alveolar macrophage, suggesting that PC-PLC is involved in the silica associated inflammatory response
Kim et al., J Immunol 2012
(Disease Models, Animal...) :
In a second model of sepsis,
PLC activation also
inhibited the production of
TNF-a and IL-1ß following systemic LPS challenge
Weber et al., Arterioscler Thromb Vasc Biol 1995
:
In addition, DHA or D609 but not eicosapentaenoic acid or arachidonic acid suppressed
activation of
PC-PLC by
TNF-alpha , estimated as [ 14C ] DAG synthesis in prelabeled HUVECs ... Incorporation of DHA into phospholipids selectively attenuates VCAM-1 induction by TNF-alpha and subsequent monocytic cell adhesion by inhibition of
TNF-alpha stimulated
PC-PLC activation in HUVECs
Alsharif et al., Pharmacology 1994
:
One day after treatment with 125 micrograms TCDD/kg,
anti-TNF-alpha resulted in 70, 27, 33 and 21 % decreases in DNA-SSB, mitochondrial and microsomal lipid peroxidation and
PLC activation, respectively, relative to TCDD treated mice
Machleidt et al., J Exp Med 1996
(Shock, Septic) :
We have investigated the
role of a TNF-responsive phosphatidylcholine-specific phospholipase C (
PC-PLC ) for the cytotoxic and proinflammatory activity of
TNF
Kimura et al., Am J Physiol 1997
:
Although TSH stimulation of H2O2 production is mediated by the phospholipase C (PLC)-Ca2+ pathway,
TNF-alpha and exogenous and endogenous ceramide
affected neither TSH dependent
PLC activation and Ca2+ mobilization nor TSH induced cAMP accumulation but attenuated Ca ( 2+ ) -induced H2O2 production
Berkovic et al., J Exp Ther Oncol 1996
(Leukemia) :
HePC inhibited fMLP induced phosphatidylinositol-specific PLC activation in HL60 cells and
TNF-alpha induced activation of phosphatidylcholine-specific
PLC in U937 cells ... Inhibition of
TNF-alpha induced
PC-PLC activation, however, seemed to be regulated at a post-receptor level as PLC inhibition and receptor occupancy did not correlate
Yorek et al., Arch Biochem Biophys 1999
(Calcium Signaling) :
However,
TNFalpha did
cause a moderate decrease in phosphatidylinositol 4,5-bisphosphate ( PIP2 ) -specific
phospholipase C (PLC) activity in 3T3-L1 adipocytes