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IGF1 — KLK3

Pathways - manually collected, often from reviews:

• Reactome Reaction: IGF1 → KLK3 (reaction) Okabe et al., FEBS Lett 1999*, Hoeflich et al., Cancer Res 2001, Mohan et al., J Endocrinol 2002, Firth et al., Endocr Rev 2002, Cohen et al., J Clin Endocrinol Metab 1992*, Holly et al., Neuroendocrinology 2006, Lee et al., J Clin Endocrinol Metab 1994*, Cohen et al., J Endocrinol 1994*, Fielder et al., Growth Regul 1994, Rajah et al., Prog Growth Factor Res 1995

Text-mined interactions from Literome

Kollara et al., J Steroid Biochem Mol Biol 2003 (Prostatic Neoplasms) : Insulin-like growth factor-I (IGF-I) , which has been shown to activate AR in the absence of ligand, did not activate PSA secretion in the absence of androgen, but further increased the dihydrotestosterone induced PSA secretion in PC-3 ( AR ) cells
Liu et al., Prostate 2011 (Adenocarcinoma...) : Functional depletion of IGF-I or IGF-I receptor diminished PSA induction