Gene interactions and pathways from curated databases and text-mining

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MIR21 — PDCD4

Text-mined interactions from Literome

Hiyoshi et al., Clin Cancer Res 2009 (Carcinoma, Squamous Cell...) : The aim of this study was ( a ) to determine a role of microRNA-21 in esophageal squamous cell carcinoma and ( b ) to elucidate the regulation of the programmed cell death 4 (PDCD4) gene by microRNA-21 ... In addition, the regulation of PDCD4 by microRNA-21 was elucidated to identify the mechanisms of this regulation
Reis et al., Molecular cancer 2010 (Carcinoma, Squamous Cell...) : We also examined PDCD4 regulation by microRNA 21 (miR-21) in OSCC
Liu et al., Chin Med Sci J 2012 (Bile Duct Neoplasms...) : The dual luciferase reporter gene assay revealed endogenous microRNA-21 in cholangiocarcinoma cell line, QBC939, inhibited the luciferase reporter activities of wild-type PTEN ( P < 0.01 ) and PDCD4 ( P < 0.05 ) and had no this effect on mutated PTEN and PDCD4