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ODC1 — PTH

Text-mined interactions from Literome

Yu et al., Endocrinology 1992 : PTH- ( 1-34 ) and forskolin also stimulated ODC activity, but PTHrP- ( 67-86 ) amide was ineffective
Cheng et al., Calcif Tissue Int 1992 : In contrast, PTH- ( 2-34 ), propionyl bPTH- ( 2-34 ), bPTH- ( 3-34 ), bPTH- ( 7-34 ), and PGF2 alpha, which only enhanced [ Ca2+ ] i but not cAMP, had no effect on ODC activity ... Thus, the stimulation of ODC in UMR106 cells by PTH appeared to be mediated primarily via the cAMP signal transduction pathway, and the mere increase in intracellular calcium could not account for the stimulation of ODC activity ... Moreover, PTH also stimulated ODC antizyme activity, suggesting that the ODC degradation rate was increased
Morimoto et al., Methods Find Exp Clin Pharmacol 1991 : Pretreatment of chondrocytes with TPA ( 10 ( -8 ) M ) for 48 h significantly enhanced DNA synthesis, inhibited glycosaminoglycan ( GAG ) synthesis and inhibited the increase in ornithine decarboxylase (ODC) activity in response to parathyroid hormone (PTH) relative to values in control cultures
Goto et al., Arch Biochem Biophys 1991 (Osteosarcoma) : Here, we studied whether parathyroid hormone (PTH) affects the induction of ODC and the proliferation of the human osteoblast-like cell line SaOS2, which is sensitive to PTH
van Leeuwen et al., J Cell Physiol 1989 : We tested the effect of protein kinase C on stimulation of ODC activity by parathyroid hormone (PTH) and forskolin ... In contrast to PTH stimulated ODC activity, which was not affected by PMA, forskolin stimulated ( 1 and 10 microM ) ODC activity was dose dependently reduced
Van Leeuwen et al., J Bone Miner Res 1989 (Second Messenger Systems) : PTH induced ODC activity and stimulated cAMP production in a dose dependent manner, the ED50 for cAMP being five times as high as that for ODC ... Induction of ODC activity by PTH was partly inhibited by actinomycin D and cycloheximide, with 40 and 55 % inhibition, respectively ... The present data indicate that ( 1 ) PTH stimulates ODC activity and this is partly due to new enzyme synthesis ; ( 2 ) calcium is involved in induction of ODC activity and stimulation of cAMP production by PTH ; furthermore, it is suggestive that calmodulin and/or protein kinase C are involved ; and ( 3 ) stimulation of cAMP production by PTH depends on an optimal intracellular calcium concentration range
Nagata et al., J Endod 1989 : PTH alone ( 1 unit per ml ) stimulated ODC activity in 1.7-fold, but did not affect DNA synthesis ... PTH plus insulin caused greater increases in ODC activity and DNA synthesis in dental pulp explants than insulin alone ( ODC, 2.6-fold ; DNA, 3.7-fold )
van Leeuwen et al., J Cell Physiol 1988 : Furthermore, these data suggest that both cAMP and calcium are involved in the induction of ODC activity by PTH and forskolin ... More precisely, ODC activity in UMR 106-01 cells can be induced by PTH and forskolin via a calcium dependent cAMP messenger system
Takano et al., Endocrinology 1985 : These studies suggested that the accumulation of cAMP and the induction of ODC by PTH are good markers of the differentiated phenotype of cultured chondrocytes
Löwik et al., Calcif Tissue Int 1986 : Applying this method we demonstrate that parathyroid hormone , PGE1, and other inducers of intracellular cAMP levels, like IBMX and forskolin can induce ODC activity in primary cultures of chicken osteoblasts
Fukuo et al., J Biochem 1986 : The dose-response curve for ODC induction by PTH was parallel to that of PTH stimulated proteoglycan synthesis both in TPA treated chondrocytes and in normal chondrocytes
Takano et al., J Dent Res 1987 : PTH also increased accumulation of cyclic AMP ( cAMP ) and the activity of ornithine decarboxylase (ODC) , a rate limiting enzyme in polyamine biosynthesis
Takigawa et al., J Cell Physiol 1981 : These findings suggest that PTH induces increase of ODC activity and expression of the differentiated phenotype of chondrocytes through increase of cAMP and that induction of OCD is closely related to expression of the differentiated phenotype of chondrocytes
Takigawa et al., Mol Cell Biochem 1982 : PTH , dibutyryl cyclic AMP ( DBcAMP ), and 8-bromo cyclic AMP ( 8-Br cAMP ) induce ornithine decarboxylase (ODC) and expression of the differentiated phenotype of chondrocytes in this cell system ... PTH did not stimulate ODC activity or expression of the differentiated phenotype of chondrocytes in the de-differentiated state
Takigawa et al., J Biochem 1979 : Calcitonin, 1,25-dihydroxyvitamin D3, and vitamin A had no stimulatory effect on the activity of ODC, and did not inhibit the induction of ODC by PTH , when added with PTH