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MMP13 — PTH

Text-mined interactions from Literome

Turner et al., Endocr Rev 2003 (Adrenal Gland Neoplasms...) : Although parathyroid tissue induces angiogenesis when autotransplanted and PTH regulates both VEGF and MMP expression, there are few studies of angiogenesis and angiogenic factors in parathyroid tumors
Charoonpatrapong-Panyayong et al., J Cell Biochem 2007 (Mechanotransduction, Cellular) : MMP-13 PTH response is regulated by a 110 bp 5 ' regulatory region, conserved across the mouse, rat, and human genes, that supports the binding of numerous transcription factors including Runx2, c-fos/c-jun, Ets-1, and nuclear matrix protein 4/cas interacting zinc finger protein ( Nmp4/CIZ ) a nucleocytoplasmic shuttling trans acting protein that attenuates PTH-driven transcription
Shimizu et al., Ann N Y Acad Sci 2007 : We have hypothesized that histone deacetylases ( HDACs ) are involved with PTH induced MMP-13 gene expression in the osteoblastic cell line, UMR 106-01
Boumah et al., Mol Endocrinol 2009 : We have previously shown that the matrix metalloproteinase-13 (MMP-13) gene is induced by PTH in osteoblastic cells as a secondary response through the protein kinase A pathway requiring the runt domain and activator protein 1 binding sites of the proximal promoter ... The knockdown of either Runx2 or p300 by RNA interference reduced PTH induced acetylation of histones H3 and H4, association of p300 with the MMP-13 promoter, and resultant MMP-13 gene transcription
Shimizu et al., J Biol Chem 2010 : HDAC4 represses matrix metalloproteinase-13 transcription in osteoblastic cells, and parathyroid hormone controls this repression ... Previously we reported that PTH induces matrix metalloproteinase-13 (MMP-13) transcription in osteoblastic cells ... PTH induces the rapid cAMP dependent protein kinase dependent release of HDAC4 from the MMP-13 promoter and subsequent transcription of MMP-13 ... Knock-out of HDAC4 either by siRNA in vitro or by gene deletion in vivo leads to an increase in MMP-13 expression, and overexpression of HDAC4 decreases the PTH induction of MMP-13
Lee et al., J Biol Chem 2010 : Parathyroid hormone activation of matrix metalloproteinase-13 transcription requires the histone acetyltransferase activity of p300 and PCAF and p300 dependent acetylation of PCAF ... We have previously shown that Mmp-13 gene expression is highly induced by PTH treatment in osteoblastic UMR 106-01 cells, as well as primary osteoblasts ... Here, we show that p300/CBP associated factor (PCAF), in addition to p300 and Runx2, is required for PTH activation of Mmp-13 transcription ... PCAF cooperates with p300 and Runx2 to mediate PTH activation of MMP-13 transcription
Peeters-Joris et al., Biochim Biophys Acta 1998 (Bone Resorption) : Furthermore, it was demonstrated that in cultures of mouse calvariae the production of MMP-13 was induced by the potent MMP-stimulator heparin and by parathyroid hormone (PTH) , whereas the levels of MMP-3 remained unchanged