◀ Back to BMP7
BMP7 — BMPR1A
Pathways - manually collected, often from reviews:
-
BioCarta alk in cardiac myocytes:
BMPR-II/ALK3 complex (BMPR2-BMPR1A)
→
BMP/BMPR-II/ALK3 complex (BMPR2-BMPR1A-BMP7_BMP2_BMP5_BMP10_BMP4)
(modification, collaborate)
-
BioCarta alk in cardiac myocytes:
BMPR-II/ALK3 complex (BMPR2-BMPR1A)
→
BMP (BMP7/BMP2/BMP5/BMP10/BMP4)
(modification, collaborate)
-
BioCarta alk in cardiac myocytes:
BMP/BMPR-II/ALK3 complex (BMPR2-BMPR1A-BMP7_BMP2_BMP5_BMP10_BMP4)
→
BMP (BMP7/BMP2/BMP5/BMP10/BMP4)
(modification, collaborate)
-
BioCarta alk in cardiac myocytes:
NOGGIN (NOG)
→
BMP/BMPR-II/ALK3 complex (BMPR2-BMPR1A-BMP7_BMP2_BMP5_BMP10_BMP4)
(modification, inhibits)
-
BioCarta alk in cardiac myocytes:
BMP/BMPR-II/ALK3 complex (BMPR2-BMPR1A-BMP7_BMP2_BMP5_BMP10_BMP4)
→
CHORDIN (CHRD)
(modification, activates)
-
NCI Pathway Database BMP receptor signaling:
BMP7/BMPR2/BMPR1A-1B/SMAD6/SMURF1 complex (BMP7-BMPR2-BMPR1A_BMPR1B-SMAD6-SMURF1)
→
SMAD6/SMURF1 complex (SMAD6-SMURF1)
(modification, collaborate)
Murakami et al., Mol Biol Cell 2003, Hoodless et al., Cell 1996, Kretzschmar et al., Genes Dev 1997, Imamura et al., Nature 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database BMP receptor signaling:
BMP7/BMPR2/BMPR1A-1B/SMAD6/SMURF1 complex (BMP7-BMPR2-BMPR1A_BMPR1B-SMAD6-SMURF1)
→
SMAD1 (SMAD1)
(modification, collaborate)
Murakami et al., Mol Biol Cell 2003, Hoodless et al., Cell 1996, Kretzschmar et al., Genes Dev 1997, Imamura et al., Nature 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database BMP receptor signaling:
BMP7/BMPR2/BMPR1A-1B/SMAD6/SMURF1 complex (BMP7-BMPR2-BMPR1A_BMPR1B-SMAD6-SMURF1)
→
BMP7/BMPR2/BMPR1A-1B complex (BMP7-BMPR2-BMPR1A_BMPR1B)
(modification, collaborate)
Murakami et al., Mol Biol Cell 2003, Hoodless et al., Cell 1996, Kretzschmar et al., Genes Dev 1997, Imamura et al., Nature 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database BMP receptor signaling:
SMAD6/SMURF1 complex (SMAD6-SMURF1)
→
BMP7/BMPR2/BMPR1A-1B complex (BMP7-BMPR2-BMPR1A_BMPR1B)
(modification, collaborate)
Murakami et al., Mol Biol Cell 2003, Hoodless et al., Cell 1996, Kretzschmar et al., Genes Dev 1997, Imamura et al., Nature 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database BMP receptor signaling:
SMAD1 (SMAD1)
→
BMP7/BMPR2/BMPR1A-1B complex (BMP7-BMPR2-BMPR1A_BMPR1B)
(modification, collaborate)
Murakami et al., Mol Biol Cell 2003, Hoodless et al., Cell 1996, Kretzschmar et al., Genes Dev 1997, Imamura et al., Nature 1997
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database BMP receptor signaling:
BMP7/BMPR2/BMPR1A-1B/FS complex (BMP7-BMPR2-BMPR1A_BMPR1B-FST)
→
FS (FST)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Liu et al., Mol Cell Biol 1995, ten Dijke et al., J Biol Chem 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
Evidence: physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP7/BMPR2/BMPR1A-1B/FS complex (BMP7-BMPR2-BMPR1A_BMPR1B-FST)
→
BMP7 (dimer) complex (BMP7)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Liu et al., Mol Cell Biol 1995, ten Dijke et al., J Biol Chem 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
Evidence: physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP7/BMPR2/BMPR1A-1B/FS complex (BMP7-BMPR2-BMPR1A_BMPR1B-FST)
→
BMPR1A-1B (homodimer) complex (BMPR1A_BMPR1B)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Liu et al., Mol Cell Biol 1995, ten Dijke et al., J Biol Chem 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
Evidence: physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP7/BMPR2/BMPR1A-1B/FS complex (BMP7-BMPR2-BMPR1A_BMPR1B-FST)
→
BMP7/BMPR2/BMPR1A-1B complex (BMP7-BMPR2-BMPR1A_BMPR1B)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Liu et al., Mol Cell Biol 1995, ten Dijke et al., J Biol Chem 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
Evidence: physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP7/BMPR2/BMPR1A-1B/FS complex (BMP7-BMPR2-BMPR1A_BMPR1B-FST)
→
BMPR2 (homodimer) complex (BMPR2)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Liu et al., Mol Cell Biol 1995, ten Dijke et al., J Biol Chem 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
Evidence: physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP7/BMPR2/BMPR1A-1B/FS complex (BMP7-BMPR2-BMPR1A_BMPR1B-FST)
→
BAMBI (BAMBI)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Liu et al., Mol Cell Biol 1995, ten Dijke et al., J Biol Chem 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
Evidence: physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP7/BMPR2/BMPR1A-1B/FS complex (BMP7-BMPR2-BMPR1A_BMPR1B-FST)
→
BMPR1A-1B/BAMBI complex (BAMBI-BMPR1A_BMPR1B)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Liu et al., Mol Cell Biol 1995, ten Dijke et al., J Biol Chem 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
Evidence: physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
FS (FST)
→
BMP7/BMPR2/BMPR1A-1B complex (BMP7-BMPR2-BMPR1A_BMPR1B)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Liu et al., Mol Cell Biol 1995, ten Dijke et al., J Biol Chem 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
Evidence: physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP7 (dimer) complex (BMP7)
→
BMPR1A-1B (homodimer) complex (BMPR1A_BMPR1B)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Liu et al., Mol Cell Biol 1995, ten Dijke et al., J Biol Chem 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
Evidence: physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP7 (dimer) complex (BMP7)
→
BMP7/BMPR2/BMPR1A-1B complex (BMP7-BMPR2-BMPR1A_BMPR1B)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Liu et al., Mol Cell Biol 1995, ten Dijke et al., J Biol Chem 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
Evidence: physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP7 (dimer) complex (BMP7)
→
BMPR1A-1B/BAMBI complex (BAMBI-BMPR1A_BMPR1B)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Liu et al., Mol Cell Biol 1995, ten Dijke et al., J Biol Chem 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
Evidence: physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMPR1A-1B (homodimer) complex (BMPR1A_BMPR1B)
→
BMP7/BMPR2/BMPR1A-1B complex (BMP7-BMPR2-BMPR1A_BMPR1B)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Liu et al., Mol Cell Biol 1995, ten Dijke et al., J Biol Chem 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
Evidence: physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP7/BMPR2/BMPR1A-1B complex (BMP7-BMPR2-BMPR1A_BMPR1B)
→
BMPR2 (homodimer) complex (BMPR2)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Liu et al., Mol Cell Biol 1995, ten Dijke et al., J Biol Chem 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
Evidence: physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP7/BMPR2/BMPR1A-1B complex (BMP7-BMPR2-BMPR1A_BMPR1B)
→
BAMBI (BAMBI)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Liu et al., Mol Cell Biol 1995, ten Dijke et al., J Biol Chem 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
Evidence: physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP7/BMPR2/BMPR1A-1B complex (BMP7-BMPR2-BMPR1A_BMPR1B)
→
BMPR1A-1B/BAMBI complex (BAMBI-BMPR1A_BMPR1B)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Liu et al., Mol Cell Biol 1995, ten Dijke et al., J Biol Chem 1994, Iemura et al., Proc Natl Acad Sci U S A 1998
Evidence: physical interaction, other species
-
NCI Pathway Database BMP receptor signaling:
BMP7/USAG1 complex (BMP7-SOSTDC1)
→
BMPR1A-1B (homodimer) complex (BMPR1A_BMPR1B)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Yanagita et al., Biochem Biophys Res Commun 2004, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Liu et al., Mol Cell Biol 1995, ten Dijke et al., J Biol Chem 1994
Evidence: physical interaction
-
NCI Pathway Database BMP receptor signaling:
BMP7/USAG1 complex (BMP7-SOSTDC1)
→
BMP7/BMPR2/BMPR1A-1B complex (BMP7-BMPR2-BMPR1A_BMPR1B)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Yanagita et al., Biochem Biophys Res Commun 2004, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Liu et al., Mol Cell Biol 1995, ten Dijke et al., J Biol Chem 1994
Evidence: physical interaction
-
NCI Pathway Database BMP receptor signaling:
BMP7/USAG1 complex (BMP7-SOSTDC1)
→
BMPR1A-1B/BAMBI complex (BAMBI-BMPR1A_BMPR1B)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Yanagita et al., Biochem Biophys Res Commun 2004, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Liu et al., Mol Cell Biol 1995, ten Dijke et al., J Biol Chem 1994
Evidence: physical interaction
-
NCI Pathway Database BMP receptor signaling:
USAG1 (SOSTDC1)
→
BMP7/BMPR2/BMPR1A-1B complex (BMP7-BMPR2-BMPR1A_BMPR1B)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Yanagita et al., Biochem Biophys Res Commun 2004, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Liu et al., Mol Cell Biol 1995, ten Dijke et al., J Biol Chem 1994
Evidence: physical interaction
-
NCI Pathway Database BMP receptor signaling:
BMP7 (dimer) complex (BMP7)
→
BMPR1A-1B (homodimer) complex (BMPR1A_BMPR1B)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Yanagita et al., Biochem Biophys Res Commun 2004, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Liu et al., Mol Cell Biol 1995, ten Dijke et al., J Biol Chem 1994
Evidence: physical interaction
-
NCI Pathway Database BMP receptor signaling:
BMP7 (dimer) complex (BMP7)
→
BMP7/BMPR2/BMPR1A-1B complex (BMP7-BMPR2-BMPR1A_BMPR1B)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Yanagita et al., Biochem Biophys Res Commun 2004, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Liu et al., Mol Cell Biol 1995, ten Dijke et al., J Biol Chem 1994
Evidence: physical interaction
-
NCI Pathway Database BMP receptor signaling:
BMP7 (dimer) complex (BMP7)
→
BMPR1A-1B/BAMBI complex (BAMBI-BMPR1A_BMPR1B)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Yanagita et al., Biochem Biophys Res Commun 2004, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Liu et al., Mol Cell Biol 1995, ten Dijke et al., J Biol Chem 1994
Evidence: physical interaction
-
NCI Pathway Database BMP receptor signaling:
BMPR1A-1B (homodimer) complex (BMPR1A_BMPR1B)
→
BMP7/BMPR2/BMPR1A-1B complex (BMP7-BMPR2-BMPR1A_BMPR1B)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Yanagita et al., Biochem Biophys Res Commun 2004, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Liu et al., Mol Cell Biol 1995, ten Dijke et al., J Biol Chem 1994
Evidence: physical interaction
-
NCI Pathway Database BMP receptor signaling:
BMP7/BMPR2/BMPR1A-1B complex (BMP7-BMPR2-BMPR1A_BMPR1B)
→
BMPR2 (homodimer) complex (BMPR2)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Yanagita et al., Biochem Biophys Res Commun 2004, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Liu et al., Mol Cell Biol 1995, ten Dijke et al., J Biol Chem 1994
Evidence: physical interaction
-
NCI Pathway Database BMP receptor signaling:
BMP7/BMPR2/BMPR1A-1B complex (BMP7-BMPR2-BMPR1A_BMPR1B)
→
BAMBI (BAMBI)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Yanagita et al., Biochem Biophys Res Commun 2004, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Liu et al., Mol Cell Biol 1995, ten Dijke et al., J Biol Chem 1994
Evidence: physical interaction
-
NCI Pathway Database BMP receptor signaling:
BMP7/BMPR2/BMPR1A-1B complex (BMP7-BMPR2-BMPR1A_BMPR1B)
→
BMPR1A-1B/BAMBI complex (BAMBI-BMPR1A_BMPR1B)
(modification, collaborate)
Onichtchouk et al., Nature 1999, Yanagita et al., Biochem Biophys Res Commun 2004, Rosenzweig et al., Proc Natl Acad Sci U S A 1995, Liu et al., Mol Cell Biol 1995, ten Dijke et al., J Biol Chem 1994
Evidence: physical interaction
-
WikiPathways Endoderm Differentiation:
BMP7
→
BMPR1A
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Murali et al., Development 2005
:
These studies provide direct genetic evidence that
Bmpr1a and Bmpr1b play redundant roles during retinal development, and that different threshold levels of
Bmp signaling
regulate distinct developmental programs such as patterning, growth and differentiation of the retina
Yoon et al., Proc Natl Acad Sci U S A 2005
(Osteochondrodysplasias) :
In summary, our study demonstrates that
BMPR1A and BMPR1B are functionally redundant during early chondrogenesis and that
BMP signaling is
required for chondrocyte proliferation, survival, and differentiation in vivo
Kano et al., Endocrinology 2005
:
Furthermore, intracellular
BMP signaling was markedly suppressed by dexamethasone treatment and the expression of ALK-2,
ALK-3 , and BMPRII was significantly
inhibited by dexamethasone
Miyoshi et al., Biol Reprod 2006
:
Since overexpression of
BMPR1A and BMPR1B, but not SMADs, significantly
enhanced the
BMP responses, these type I receptors were revealed to be limiting factors for BMP signaling in KGN cells
Huang et al., Proc Natl Acad Sci U S A 2009
:
Overexpression of constitutively active
BMP receptor ( CA ) -BMPr1A or CA-BMPr1B
induces commitment in the absence of BMP2/4, whereas overexpression of a dominant negative receptor
dominant-negative-BMPr1A suppresses commitment induced by BMP