◀ Back to EPHB2
EPHB1 — EPHB2
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Ephrin B reverse signaling:
Ephrin B1/EPHB1-2 complex (EFNB1-EPHB1_EPHB2)
→
Ephrin B1/EPHB1-2/Src Family Kinases complex (EFNB1-EPHB1_EPHB2-FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN)
(modification, collaborate)
Palmer et al., Mol Cell 2002
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database EPHB forward signaling:
EPHB1-2 (EPHB1/EPHB2)
→
Ephrin B1/EPHB1-2 complex (EFNB1-EPHB1_EPHB2)
(modification, collaborate)
Davis et al., Science 1994, Gale et al., Neuron 1996, Holland et al., Nature 1996*
Evidence: assay, physical interaction
-
NCI Pathway Database Ephrin B reverse signaling:
EPHB1-2 (EPHB1/EPHB2)
→
Ephrin B2/EPHB1-2 complex (EFNB2-EPHB1_EPHB2)
(modification, collaborate)
Davis et al., Science 1994, Gale et al., Neuron 1996
Evidence: assay, physical interaction
-
NCI Pathway Database EPHB forward signaling:
EPHB1-2 (EPHB1/EPHB2)
→
Ephrin B2/EPHB1-2 complex (EFNB2-EPHB1_EPHB2)
(modification, collaborate)
Davis et al., Science 1994, Gale et al., Neuron 1996
Evidence: assay, physical interaction
-
NCI Pathway Database Ephrin B reverse signaling:
Ephrin B1/EPHB1-2/Tiam1 complex (EFNB1-EPHB1_EPHB2-TIAM1)
→
Ephrin B1/EPHB1-2 complex (EFNB1-EPHB1_EPHB2)
(modification, collaborate)
Tanaka et al., EMBO J 2004
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Ephrin B reverse signaling:
Ephrin B1/EPHB1-2 complex (EFNB1-EPHB1_EPHB2)
→
Ephrin B1/EPHB1-2/RGS3 complex (EFNB1-EPHB1_EPHB2-RGS3)
(modification, collaborate)
Lu et al., Cell 2001
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Ephrin B reverse signaling:
EPHB1-2 (EPHB1/EPHB2)
→
Ephrin B1/EPHB1-2 complex (EFNB1-EPHB1_EPHB2)
(modification, collaborate)
Davis et al., Science 1994, Gale et al., Neuron 1996, Holland et al., Nature 1996*
Evidence: assay, physical interaction
-
NCI Pathway Database EPHB forward signaling:
Ephrin B1/EPHB1-2/NCK1 complex (EFNB1-EPHB1_EPHB2-NCK1)
→
Ephrin B1/EPHB1-2 complex (EFNB1-EPHB1_EPHB2)
(modification, collaborate)
Stein et al., J Biol Chem 1998*
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database Ephrin B reverse signaling:
Ephrin B1/EPHB1-2 complex (EFNB1-EPHB1_EPHB2)
→
Ephrin B1/EPHB1-2/NCK2 complex (EFNB1-EPHB1_EPHB2-NCK2)
(modification, collaborate)
Cowan et al., Nature 2001
Evidence: physical interaction
-
Reactome Reaction:
EPHB2
→
EPHB1
(reaction)
van Horck et al., J Biol Chem 2001, Marignani et al., J Cell Biol 2001, Bokoch et al., Annu Rev Biochem 2003, Zhang et al., J Cell Biol 2003, Marston et al., Nat Cell Biol 2003, Zhang et al., J Neurosci 2005, Cowan et al., Neuron 2005, Tolias et al., Proc Natl Acad Sci U S A 2007, Zhang et al., Nature 1990, Yao et al., Oncogene 1995
Text-mined interactions from Literome
Cho et al., J Biol Chem 2003
:
We reduced the level of caveolin-1 in senescent human diploid fibroblasts using its antisense oligonucleotides and small interfering RNA, and this resulted in the restoration of normal growth factor responses such as the increased phosphorylation of
Erk , the nuclear translocation of p-Erk, and the subsequent
activation of
p-Elk upon epidermal growth factor stimulation
Vindis et al., J Cell Biol 2003
:
Expression of dominant negative c-Src significantly reduced
EphB1 dependent
ERK1/2 activation and chemotaxis ... Together these findings highlight a new aspect of
EphB1 signaling, whereby the concerted action of c-Src and p52Shc
activates MAPK/ERK and regulates events involved in cell motility
Lee et al., Infect Immun 2005
:
Our data indicate that the increased Ets/Elk and NF-kappaB promoter activities associated with M. smegmatis infected macrophages are responsible, at least in part, for the increased TNF-alpha and NOS2 production observed in these infected cells and that
ERK1/2 is
required for
Ets/Elk activity and full TNF-alpha production
Vihanto et al., J Cell Sci 2006
:
This interaction, as well as
EphB1 mediated activation of extracellular-signal regulated kinase (
ERK ), was abrogated by overexpression of a caveolin-1 mutant lacking a functional scaffolding domain