Gene interactions and pathways from curated databases and text-mining

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EFNB2 — EPHB2

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Takasu et al., Science 2002 : EphrinB2 activation of EphB in primary cortical neurons potentiates NMDA receptor dependent influx of calcium
Kim et al., FASEB J 2002 (MAP Kinase Signaling System) : EphrinB2 not only increased the phosphorylation of EphB2 and EphB4 in a time dependent manner but also increased recruitment of p120-Ras-GTPase activating protein ( p120-RasGAP ) to EphB2 and EphB4
Mann et al., J Neurobiol 2003 : Forward and reverse signaling mediated by EphB tyrosine kinase receptors and their transmembrane ephrin-B ligands play important roles in axon pathfinding, yet little is known about the intracellular pathways involved
Henkemeyer et al., J Cell Biol 2003 : We show further that a kinase-defective, truncating mutation in EphB2 also results in abnormal spine development and that ephrin-B2 mediated activation of the EphB receptors accelerates dendritic spine development
Georgakopoulos et al., EMBO J 2006 : Here we show that EphB stimulates a metalloproteinase cleavage of ephrinB2 , producing a carboxy-terminal fragment that is further processed by PS1/gamma-secretase to produce intracellular peptide ephrinB2/CTF2 ... PS1 FAD and gamma-secretase dominant negative mutants inhibited the EphB induced cleavage of ephrinB2 and Src autophosphorylation, raising the possibility that FAD mutants interfere with the functions of Src and ephrinB2 in the CNS
Prestoz et al., Neuron Glia Biol 2004 : In addition, we demonstrate that coated EphB2-Fc receptors, which are specific for ephrinB2/B3 ligands, induce dramatic changes in the contact and migratory properties of OPCs, indicating that axonal EphB receptors activate ephrinB signaling in OPCs.Based on these findings, we propose that OPCs are characterized by an ephrin code, and that Eph-ephrin interactions between axons and OPCs control the distribution of OPCs in the optic axonal tracts, and the progress and arrest of their migration
Lin et al., J Biol Chem 2008 : We found that EphB2 is cleaved by MMPs both in vitro and in vivo, and that this cleavage is induced by interaction with its ligand ephrin-B2
Bush et al., Genes Dev 2009 : In addition to the ability of ephrin-B1 to forward signal through its cognate EphB tyrosine kinase receptors, ephrin-B1 can also act as a receptor and transduce a reverse signal by either PDZ dependent or phosphorylation dependent mechanisms
Li et al., J Neurosci 2011 : These data provide evidence for ephrin-B induced EphB2 forward signaling in presynaptic structural plasticity during classical conditioning
Georgakopoulos et al., FASEB J 2011 : Presenilin1/gamma-secretase promotes the EphB2 induced phosphorylation of ephrinB2 by regulating phosphoprotein associated with glycosphingolipid enriched microdomains/Csk binding protein ... EphB2 induced tyrosine phosphorylation of ephrinB2 depends on PAG/Cbp because EphB2 can not increase ephrinB2 phosphorylation in cells treated with anti-PAG siRNA or in PAG/Cbp-knockout ( KO ) cells ... Furthermore, in contrast to WT PS1, familial Alzheimer disease ( FAD ) PS1 mutants expressed in PS1-KO mouse embryonic fibroblasts inhibited both the EphB2 induced dephosphorylation of PAG/Cbp and the phosphorylation of ephrinB2
Muñoz et al., Neuroimmunomodulation 2011 : In addition, EphB2 and EphB3 play a cell-autonomous role in regulating the transitions of double negative to double positive cells and of double positive to single positive thymocytes and the lack of these molecules or their ligands ephrin B1 and ephrin B2 induces profound alterations of the TEC maturation and in the arrangement of epithelial network
Barthet et al., Neurobiol Aging 2013 : Activation of EphB receptors by ephrinB ( efnB ) ligands on neuronal cell surface regulates important functions, including neurite outgrowth, axonal guidance, and synaptic plasticity
Srivastava et al., Mol Cell Neurosci 2013 : Taken together, our findings suggest that ephrinB activated EphB2 receptors recruit a novel Nck/Pak signaling complex to mediate repulsive cortical growth cone guidance, which may be relevant for EphB forward signaling dependent axon guidance in vivo