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CRH — VEGFA

Text-mined interactions from Literome

Cao et al., J Immunol 2005 : Human mast cells express corticotropin releasing hormone (CRH) receptors and CRH leads to selective secretion of vascular endothelial growth factor ... CRH increased cAMP and induced secretion of vascular endothelial growth factor ( VEGF ) without tryptase, histamine, IL-6, IL-8, or TNF-alpha release ... CRH stimulated VEGF production was mediated through activation of adenylate cyclase and increased cAMP, as evidenced by the fact that the effect of CRH was mimicked by the direct adenylate cyclase activator forskolin and the cell-permeable cAMP analog 8-bromo-cAMP, whereas it was abolished by the adenylate cyclase inhibitor SQ22536 ... This is the first evidence that mast cells express functional CRH receptors and that CRH can induce VEGF secretion selectively
Cao et al., Mol Pharmacol 2006 : Corticotropin releasing hormone induces vascular endothelial growth factor release from human mast cells via the cAMP/protein kinase A/p38 mitogen activated protein kinase pathway ... However, the precise mechanism by which CRH induces VEGF secretion has not yet been defined ... Here, we show that CRH induced VEGF release was dose-dependently inhibited by the specific protein kinase A inhibitor N- [ 2- ( 4-bromocinnamylamino ) ethyl ] -5-isoquinoline ( H89 ) or the p38 mitogen activated protein kinase ( MAPK ) inhibitor 4- ( 4-fluorophenyl ) -2- ( 4-methylsulfinylphenyl ) -5- ( 4-pyridyl ) 1H-imidazole ( SB203580 ) but not by the specific inhibitor 2'-amino-3'-methoxyflavone ( PD98059 ) of mitogen activated protein kinase kinase, the upstream kinase of the extracellular signal regulated protein kinase ( ERK ) or the c-Jun N-terminal kinase (JNK) inhibitor 1,9-pyrazoloanthrone anthra- ( 1,9-cd ) pyrazol-6 ( 2H ) -one ( SP600125 ) ... These results indicate that CRH induces VEGF release in human mast cells via selective activation of the cAMP/protein kinase A/p38 MAPK signaling pathway, thereby providing further insight into the molecular mechanism of how CRH affects the release of a key proinflammatory mediator
Cao et al., J Urol 2006 (Acute Disease) : Acute stress and intravesical corticotropin releasing hormone induces mast cell dependent vascular endothelial growth factor release from mouse bladder explants ... We investigated the effect of intravesical corticotropin releasing hormone and acute restraint stress on vascular endothelial growth factor release from mouse bladder explants and the role of mast cells ... Corticotropin releasing hormone ( 100 nM ) or acute restraint stress ( 4 hours ) increased histamine release in urine and vascular endothelial growth factor release in medium without increasing interleukin-6 or tumor necrosis factor-alpha in the bladder explants of C57BL/6 or +/+ but not W/W ( v ) mice ... Intravesical corticotropin releasing hormone and acute restraint stress induced mast cell dependent vascular endothelial growth factor release from bladder explants
Kamat et al., Cancer Lett 2007 (Anoxia...) : In addition, we found increased HIF mediated transactivation and increased VEGF release with decreased HIF-1alpha/p53 and HIF-1alpha/MDM-2 partnering in p53-MUT versus p53-WT cells in response to CRH
Wakahashi et al., Endocrine 2008 : Effects of corticotropin releasing hormone and stresscopin on vascular endothelial growth factor mRNA expression in cultured early human extravillous trophoblasts ... In the present study, we investigated the effects of CRH and SCP on VEGF expression in early placental extravillous trophoblasts ( EVTs ) ... The effects of CRH and SCP on VEGF mRNA levels in cultured EVTs were assessed by real-time RT-PCR ... We demonstrated that CRH and SCP inhibited VEGF mRNA expression in cultured EVTs through the interaction with CRHR-2, suggesting that CRH and SCP may inhibit angiogenesis during early placentation
Zhou et al., Regul Pept 2010 : To determine whether CRH and its receptor, CRH-R1, modulate the expression of vascular endothelial growth factor ( VEGF ), which is overexpressed in psoriatic epidermis and plays a causal role in the pathogenesis of psoriasis, we investigated the effect of CRH on the expression of VEGF in a human keratinocyte cell line ( HaCaT ) and whether this effect is via the mitogen activated protein kinase ( MAPK ) signal transduction pathways ... However, this downregulation was abrogated by pretreatment with antalarmin, SB203580 and SP600125 ; pretreatment with PD98059 did not attenuate the effects of CRH on the expression of VEGF
Boucher et al., BJU Int 2010 (Acute Disease...) : Corticotropin releasing hormone-receptor 2 is required for acute stress induced bladder vascular permeability and release of vascular endothelial growth factor
Asadi et al., Journal of neuroinflammation 2012 : Corticotropin releasing hormone and extracellular mitochondria augment IgE stimulated human mast-cell vascular endothelial growth factor release, which is inhibited by luteolin ... CRH augmented IgE/anti-IgE induced human mast-cell release of VEGF and it also induced the expression of IgE receptor ( FceRI ) on mast cells
Alysandratos et al., PloS one 2012 : Here we show that NT triggered human mast cell degranulation and significantly augmented CRH induced vascular endothelial growth factor ( VEGF ) release