Gene interactions and pathways from curated databases and text-mining

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CDKN1A — CISH

Text-mined interactions from Literome

Ueno et al., J Biol Chem 1999 (Colonic Neoplasms) : cis-Diamminedichloroplatinum ( II ) ( CDDP ) induced p53 activation and p21 transactivation
Hayashi et al., Cancer Lett 2000 (Carcinoma, Squamous Cell...) : Interestingly, 9-cis-RA induced transiently the expression of p21 ( Waf1/Cip1 ), p27 ( Kip1 ), p300, CBP, BAX, Bak and bcl-2 proteins, respectively
Boosalis et al., Blood 2001 : These findings suggest that the absence of bulk histone hyperacetylation and p21 induction , but prolonged induction of cis , myb, myc, and STAT-5 activation, contribute to the cellular proliferation induced by selected SCFADs
Kannan-Thulasiraman et al., Biochem Biophys Res Commun 2008 (Leukemia, Promyelocytic, Acute) : Our data also establish that ATRA- or cis-RA dependent p21 ( Waf1/Cip1 ) protein expression is enhanced in mouse embryonic fibroblasts with targeted disruption of the 4e-bp1 gene, in the absence of any effects on the transcriptional regulation of the p21 ( Waf1/Cip1 ) gene