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NOX1 — SIRT1
Text-mined interactions from Literome
Rippe et al., Aging Cell 2010
:
OAL had increased expression and activity of the oxidant enzyme, NADPH oxidase, and its inhibition ( apocynin ) improved EDD, whereas
NADPH oxidase in OCR was similar to Y. Manganese SOD activity and
sirtuin1 expression were
reduced in OAL ( P < 0.05 ), but restored to Y in OCR
Zarzuelo et al., Biochem Pharmacol 2013
:
SIRT1 inhibits
NADPH oxidase activation and protects endothelial function in the rat aorta : Implications for vascular aging ... Inhibition of
SIRT1 significantly
increased vascular superoxide production, enhanced
NADPH oxidase activity, and mRNA expression of its subunits p22(phox) and NOX4, which were prevented by resveratrol