Gene interactions and pathways from curated databases and text-mining

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HRAS — SLC2A4RG

Text-mined interactions from Literome

Gotoh et al., J Biol Chem 2000 (Breast Neoplasms) : In contrast to several other Ral-GEFs, the Ral GEF activity of AND-34 is not augmented by constitutively active Ha-Ras ( Val-12 ), consistent with the absence of a detectable Ras binding domain
Keiper et al., J Biol Chem 2004 (MAP Kinase Signaling System) : Finally, we have demonstrated that activation of H-Ras and ERK1/2 requires the lipase activity of PLC-epsilon and the subsequent [ Ca2+ ] i increase, suggesting that H-Ras activation is mediated by a Ca2+ -activated GEF
Rubio et al., Biochem J 2006 (MAP Kinase Signaling System) : Using a cell-permeabilization approach to monitor nucleotide exchange on Ras, we demonstrate that PE-induced Ras-GTP accumulation results from GEF stimulation