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ANGPT2 — GPI
Text-mined interactions from Literome
Jaimes et al., Kidney Int 2005
:
In mesangial cells,
Ang II significantly
increased mesangial cell PGE ( 2 ) ( 200 % ) and
PGI ( 2 ) ( 100 % ) production as well as COX-2 mRNA that was prevented by the angiotensin type 1 (AT1) receptor blocker irbesartan and the COX-2 inhibitor NS-398
Furuya et al., FASEB J 2013
(Hypertension...) :
Interestingly, SphK1-knockout mice inhibited prostaglandin E ( 2 ) ( PGE ( 2 ) ) but not
PGI ( 2 ) production in
response to
Ang II , whereas celecoxib blocked both PGE ( 2 ) and PGI ( 2 ) production
Nakagawa et al., J Cardiovasc Pharmacol 1987
:
In rat aortic rings, ANG I,
ANG II , and BK enhanced whereas captopril ( 10 ( -3 ) M )
attenuated PGI2 generation
Miyamori et al., Clin Exp Hypertens A 1985
(Body Weight...) :
PGI2 generation which was measured by 6-keto-PGF1 alpha output in the perfusate was significantly reduced in DX treated rats at prehypertensive stage both under the basal conditions and in
response to angiotensin
(ANG) II , whereas in DOCA group rats, vascular PGI2 production was not impaired
Spatz et al., Am J Physiol 1994
:
ANG II maximally
stimulated PGI2 secretion during the 4- to 8-h interval, whereas AVP did not stimulate PGI2 secretion
CamiliĆ³n de Hurtado et al., Circ Res 1998
:
Under this condition,
Ang II increased
pHi from 7.05+/-0.05 to 7.22+/-0.05 ( P < .05 )