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AKT3 — POLDIP2

Text-mined interactions from Literome

Baudhuin et al., Mol Pharmacol 2002 : Akt activation induced by lysophosphatidic acid and sphingosine-1-phosphate requires both mitogen activated protein kinase kinase and p38 mitogen activated protein kinase and is cell-line specific
Motley et al., Hypertension 2003 : By contrast, an epidermal growth factor receptor inhibitor ( AG1478 ), a p42/44 mitogen activated protein kinase ( MAPK ) kinase inhibitor ( PD 598,059 ), and a p38 MAPK inhibitor ( SB 203,580 ) did not block the Ang II-induced inhibition of Akt phosphorylation
Endo et al., J Recept Signal Transduct Res 2003 : Inhibition of VEGFR-2 blocked activation of extracellular regulated-kinase, p38, Akt , and endothelial nitric oxide synthetase ( eNOS ) by VEGF, but did not inhibit p38 activation by the VEGFR-1-specific ligand, placental growth factor ( PIGF )
Lee et al., Circulation 2004 : Simvastatin activated p38 and Akt in VSMCs, and the respective inhibitors of p38 and phosphoinositide 3-kinase (PI3K) greatly reduced the level of simvastatin induced HO-1, which suggests the involvement of p38 and the PI3K-Akt pathway in HO-1 induction
Ramsauer et al., Mol Biol Cell 2006 : Consistent with the more differentiated phenotype of the CACO-2 cells, p38 phosphorylation was robustly increased by Muc4 expression, with a consequent activation of Akt
Park et al., Cancer Res 2006 (Glioblastoma...) : In addition, inhibitors of epidermal growth factor receptor ( EGFR ; AG490 and AG1478 ), Src ( PP2 ), and p38 ( SB203580 ), EGFR neutralizing antibody, and transfection of DN-Src and DN-p38 significantly blocked IR-induced Akt phosphorylation and MMP-2 secretion
Pozsgai et al., Int J Cancer 2010 (Brain Neoplasms...) : A major decrease in the levels of phospho-Akt , phospho-GSK3ß and phosho-ERK 1/2 was detected at 5 and 10 min following treatment with the GHRH antagonists, whereas elevated levels of phospho-p38 were observed at 24 hr
Sun et al., Int J Oncol 2011 : TRAIL induced caspase/p38 activation is responsible for the increased catalytic and invasive activities of Akt
Li et al., Neurobiol Aging 2012 (Alzheimer Disease...) : In SK-NS-H cells, upregulation of AGEs receptor ( RAGE ), inhibition of Akt , and activation of glycogen synthase kinase-3 ( GSK-3 ), Erk1/2, and p38 were observed after treatment with AGEs
Peart et al., Rejuvenation Res 2012 (Ischemia...) : CR counters age effects on postischemic dysfunction/cell death ; this is associated with reversal of age effects on p70S6K, augmentation of Akt and Bcl2 levels, and preischemic p38-MAPK activation
Suwanabol et al., Am J Physiol Heart Circ Physiol 2012 (Carotid Artery Injuries) : Overexpression of Smad3 enhanced p38 phosphorylation and inhibition of p38 with a chemical inhibitor or a small interfering RNA blocked TGF-ß induced Akt phosphorylation