◀ Back to SETD2

SETD2 — VLDLR

Text-mined interactions from Literome

Perman et al., J Clin Invest 2011 (Myocardial Infarction...) : Hypoxia induced VLDLR expression in HL-1 cells was dependent on HIF-1a through its interaction with a hypoxia-responsive element in the Vldlr promoter, and VLDLR promoted the endocytosis of lipoproteins
Shen et al., Biochem J 2012 (Anoxia) : The results of the present study suggest that HIF-1 mediated VLDLR induction influences intracellular lipid accumulation through regulating LDL and VLDL uptake under hypoxia
Sundelin et al., Biochem Biophys Res Commun 2013 (Anoxia) : In this study, we have thoroughly mapped the 5'-flanking region of the mouse VLDLr promoter and show that the hypoxia mediated increase in VLDLr expression is dependent on Hif-1a binding to a hypoxia responsive element ( HRE ) located at -162 to -158bp 5'of translation start ... Using a chromatin immunoprecipitation ( ChIP ) assay, we show that Hif-1a specifically binds and activates the mouse VLDLr promoter at the previously described non-classical HRE in HL-1 cells ... These results conclude that in the hypoxic hearts of mice and men, the VLDLr gene is regulated by a direct binding of Hif-1a to the VLDLr promoter