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CD79A — PTH

Text-mined interactions from Literome

Jiang et al., Clin Immunol Immunopathol 1992 : PTH also inhibited IgG, IgM, and IgA production by tonsillar B cells stimulated with Staphylococcus aureus Cowan strain I ( SAC ) and IL-6 without affecting proliferation
Gaciong et al., Kidney Int 1991 (Kidney Failure, Chronic...) : The data show that : ( 1 ) immunoglobulin production is impaired in dialysis patients ; ( 2 ) B cells of dialysis patients have elevated resting levels of cytosolic calcium ; ( 3 ) PTH inhibits IgG, IgA and IgM production and this effect is at least partly mediated by PTH induced cAMP production and alterations in cytosolic calcium into B cells ; ( 4 ) this inhibitory effect is mediated by events that affect initial stages of B cell proliferation and maturation ; ( 5 ) the requirement for high dose of PTH for its inhibitory effect on B cells from dialysis patients is probably due to desensitization and/or down-regulation of PTH receptors on B cells