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TLR3 — TNFSF11

Text-mined interactions from Literome

Kim et al., Immunol Lett 2007 (Arthritis, Rheumatoid...) : This study was undertaken to explore the effect of toll-like receptor ( TLR ) signaling in fibroblast-like synoviocytes ( FLS ) on the expression of RANKL and induction of osteoclastogenic activity ... Inhibition of TLR induced IL-1beta production, which partially reversed the upregulation of RANKL induced by TLR ligands
Kim et al., Immunol Lett 2009 (Arthritis, Rheumatoid...) : TLR3 activation induced RANKL expression in RA-FLS, but not in OA-FLS or in normal skin fibroblasts ... Inhibition of IL-1beta reversed the TLR3 induced upregulation of RANKL expression ... TLR3 induces RANKL expression indirectly in RA-FLS, and the expression of RANKL promotes the differentiation of osteoclasts in the RA synovium