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EPHB2 — HMGB1

Text-mined interactions from Literome

Kawahara et al., Int J Mol Med 2008 (Atherosclerosis...) : HMGB1 induced the activation of p38MAPK, ERK1/2 and Akt
Hayakawa et al., Glia 2010 : Role of ERK map kinase and CRM1 in IL-1beta stimulated release of HMGB1 from cortical astrocytes
Ranzato et al., Cell Biochem Biophys 2010 (MAP Kinase Signaling System) : Western blot analysis showed that HMGb1 activates ERK1/2 , while the use of an anti-RAGE receptor blocking antibody and of the selective MEK1/2 inhibitor PD98059 blocked ERK1/2 activation and wound healing responses to HMGb1
García-Arnandis et al., Arthritis Res Ther 2010 (MAP Kinase Signaling System...) : HMGB1 also enhanced the phosphorylated ERK1/2 and p38 levels, with a lower effect on phosphorylated Akt
Feng et al., Int Immunopharmacol 2013 (Diabetes Mellitus...) : Immunofluorescence and Western blotting assays showed that CM1 could attenuate HMGB1 induced intracellular ERK1/2 and NF-kB activation in HUVECs
Mohammad et al., Exp Eye Res 2013 (Diabetes Mellitus, Experimental...) : Our findings provide evidence that in the diabetic retina, HMGB-1 possibly interacts with RAGE and activates ERK ( 1/2 ) and NF-?B to generate an inflammatory response and disrupt retinal vascular barrier
Lu et al., J Interferon Cytokine Res 2013 : HMGB1 induced activity of ERK1/2 and p38 was not fully inhibited in the presence of U0126 or SB203580