Gene interactions and pathways from curated databases and text-mining

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NOTCH3 — TNF

Pathways - manually collected, often from reviews:

  • WikiPathways Notch Signaling Pathway: APH1A/APH1B/TNF/PSEN1/PSEN2/NCSTN → NOTCH2/NOTCH3/NOTCH4/NOTCH1 (activation)

Text-mined interactions from Literome

Ando et al., Oncogene 2003 (Arthritis, Rheumatoid) : We found that TNF induced the expression of Notch-1, Notch-4 , and Jagged-2 in RSF
Jiao et al., Clin Dev Immunol 2012 (Arthritis, Rheumatoid) : The aim of this paper was to investigate whether Notch signaling mediated TNF-a induced cytokine production of cultured fibroblast-like synoviocytes ( FLSs ) from RA