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CASP5 — HUNK
Text-mined interactions from Literome
Sol et al., J Virol 1999
(Parvoviridae Infections) :
Since
B19- and NS-1 induced apoptosis was
inhibited by
caspase 3, 6, and 8 inhibitors, and substantial caspase 3, 6, and 8 activities were induced by NS-1 expression, there may have been interactions between NS-1 and the apoptotic pathways of the death receptors tumor necrosis factor receptor 1 and Fas
Shen et al., Adv Cancer Res 2001
(Neoplasms) :
p53 mediated apoptosis can be blocked at multiple death checkpoints, by inhibiting p53 activity directly, by Bcl-2 family members regulating mitochondrial function, by
E1B 19K blocking
caspase-9 activation, and by caspase inhibitors
Han et al., Mol Cell Biol 1998
:
Thus,
E1B 19K functions through interacting with CED-4, and presumably a mammalian homologue of CED-4, to
inhibit caspase activation and apoptosis