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NTRK2 — PI3

Text-mined interactions from Literome

Goggi et al., Brain Res 2003 : Three proteins mediating signalling pathways are activated by the binding of BDNF to TrkB : phosphoinositol-3 kinase (PI3K) ; Ras-MEK and phospholipase C-gamma ( PLCgamma )
Leeds et al., Neurochem Int 2005 : These results show that neurotrophins protect against AraC induced apoptosis, at least in part, through TrkB mediated activation of the PI 3-kinase/Akt and MEK signaling pathways
Van't Veer et al., J Neurosci Res 2009 : TrkB can activate the mitogen- activated protein kinase ( MAPK ), phosphatidylinositol-3 kinase (PI3-K) , and phospholipase C-gamma (PLC-gamma) pathways
Cheng et al., Proc Natl Acad Sci U S A 2011 : Second, BDNF/TrkB signaling activates PI3-kinase that promotes anterograde transport of TrkB in the putative axon, further enhancing local BDNF/TrkB signaling