◀ Back to FGF2

FGF2 — ITGAV

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: Complex of ITGAV-ITGB3 → FGF2 (increases, FGF2 Activity)
  Evidence: VEGF165 also influenced the interaction of HUVECs with the prototypic ligand for aVb3, vitronectin bFGF did augment cell migration onto vitronectin, almost as effectively as VEGF165. The bFGF-stimulated migration also was inhib- ited by c7E3 (data not shown). Thus, both major angio- genic growth factors enhanced HUVEC migration in an aVb3- dependent fashion.
• OpenBEL Selventa BEL large corpus: Complex of ITGAV-ITGB3 → FGF2 (increases)
  Evidence: alpha2beta1 is upregulated by VEGF, alphaVbeta3 and alpha5beta1 are not, but instead are induced by bFGF, TNF and other angiogenic cytokines
• OpenBEL Selventa BEL large corpus: Complex of ITGAV-ITGB3 → FGF2 (increases, FGF2 Activity)
  Evidence: Similar to classical adhesive proteins, FGF2 binds avb3 [136]. Consequently, immobilized FGF2 promotes endothelial cell adhesion and spreading, leading to uPA upregulation, cell migration, proliferation, and morphogenesis [137].
• OpenBEL Selventa BEL large corpus: Complex of ITGAV-ITGB3-VTN → FGF2 (increases)
  Evidence: VEGF165 also influenced the interaction of HUVECs with the prototypic ligand for aVb3, vitronectin bFGF did augment cell migration onto vitronectin, almost as effectively as VEGF165. The bFGF-stimulated migration also was inhib- ited by c7E3 (data not shown). Thus, both major angio- genic growth factors enhanced HUVEC migration in an aVb3- dependent fashion.
• NCI Pathway Database Integrins in angiogenesis: alphav/beta3 Integrin complex (ITGAV-ITGB3) → FGF2 (FGF2) (modification, activates) Naik et al., Blood 2003, Eliceiri et al., J Cell Biol 1998
  Evidence: mutant phenotype, assay, other species
• NCI Pathway Database Integrins in angiogenesis: alphav/beta3 Integrin/JAM-A complex (F11R-ITGAV-ITGB3) → FGF2 (FGF2) (modification, collaborate) Naik et al., Blood 2003
  Evidence: mutant phenotype, assay

Text-mined interactions from Literome

Barillari et al., J Immunol 1999 (Sarcoma, Kaposi) : Tat angiogenic effects correlate with the expression of the alpha v beta 3 integrin that is induced by bFGF and binds the arginine-glycine-aspartic acid ( RGD ) region of Tat
Shono et al., Exp Cell Res 2001 : The alpha(v)beta(3) integrin is essential for fibroblast growth factor ( FGF ) -induced angiogenesis in vivo
Sepp et al., J Invest Dermatol 1994 : Basic fibroblast growth factor increases expression of the alpha v beta 3 integrin complex on human microvascular endothelial cells
Rusnati et al., Mol Biol Cell 1997 : alphavbeta3 integrin mediates the cell-adhesive capacity and biological activity of basic fibroblast growth factor ( FGF-2 ) in cultured endothelial cells