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EGF — TIMP1

Text-mined interactions from Literome

Qiu et al., Reproduction 2004 (MAP Kinase Signaling System) : EGF induced trophoblast secretion of MMP-9 and TIMP-1 involves activation of both PI3K and MAPK signalling pathways ... We showed for the first time that EGF activated both PI3K/Akt and MAPK/extracellular-signal regulated kinase ( ERK ) signalling in HTR8/SVneo, and increased both MMP-9 and TIMP-1 mRNAs and protein concentrations ... Our results suggest that the activation of both PI3K and MAPK pathways in extravillous trophoblasts is necessary for the up-regulation of MMP-9 and TIMP-1 expression by EGF
Soula-Rothhut et al., Exp Cell Res 2005 (Carcinoma...) : The tumor suppressor PTEN inhibits EGF induced TSP-1 and TIMP-1 expression in FTC-133 thyroid carcinoma cells ... In FTC-133 cells, EGF induced proliferation in a TSP-1- and TIMP-1 dependent manner ... EGF induced TSP-1 and TIMP-1 promoter activity and protein expression were inhibited in FTC-133 cells stably expressing wtPTEN but not in cells expressing mutant PTEN
Cury et al., Arch Oral Biol 2007 : The gene expression of MMP-2, TIMP-1 and 2 was not affected by EGF ( p < 0.05 )
Dilly et al., Mol Reprod Dev 2010 : Epidermal growth factor (EGF) induces motility and upregulates MMP-9 and TIMP-1 in bovine trophoblast cells ... The aim of this in vitro study was to examine EGF mediated effects on cell motility, proliferation, and MMP-9 and TIMP-1 expression in cultured bovine trophoblast cells
Pan et al., Invest Ophthalmol Vis Sci 2011 : Hypertonicity induced EGF receptor (EGFR) transactivation was suppressed by preincubating HCECs with capsazepine, matrix metalloproteinase 1 (MMP1) inhibitor TIMP-1 , broad-spectrum MMP inhibitor GM 6001, heparin bound (HB)-EGF inhibitor CRM 197, or EGFR inhibitor AG 1478
Hosono et al., FEBS Lett 1996 : This early effect of EGF on the enhanced production of proMMP-3 and TIMP-1 was not inhibited by actinomycin D, even though actinomycin D inhibited the synthesis of the total RNA in both the EGF treated and untreated cells ... These results indicate that EGF enhances the apparent production of proMMP-3 and TIMP-1 by two mechanisms : one by the accelerated translation of their mRNAs ; and the other by the enhanced transcription of their genes
Festuccia et al., Int J Cancer 1998 (Neoplasm Invasiveness...) : Similarly to EGF , bombesin stimulates secretion and activation of MMP-9 and TIMP-1 production