◀ Back to IL6

IL6 — KITLG

Text-mined interactions from Literome

Sui et al., Blood 1999 : The addition of monoclonal antibodies against gp130 to the suspension and clonal cultures completely abrogated the megakaryopoiesis induced by sIL-6R/IL-6 in the presence of SCF , whereas an anti-TPO antibody did not, indicating that the observed megakaryopoiesis by sIL-6R/IL-6 is a response to gp130 signaling and independent of TPO
Peters et al., Exp Hematol 2001 : Moreover, on murine NIH/3T3 fibroblasts and on human primary forskin fibroblasts, stimulation with the IL-6/sIL-6R complex, and to a lesser extent with IL-6 alone, led to induction of cellular SCF and Flt-3L expression ... We showed that IL-6 in combination with its soluble receptor stimulates cellular SCF and Flt-3L expression in vivo and in vitro ... Cellular upregulation of SCF and Flt-3L by IL-6/sIL-6R might be used for the development of new stroma cell systems for ex vivo expansion of hematopoietic progenitor cells
Babina et al., J Leukoc Biol 2004 (Inflammation) : Additionally, strong up-regulation of IL-6 by SCF was observed, which was inhibited by IL-4
Bouchelouche et al., J Urol 2006 : Furthermore, IL-1beta and tumor necrosis factor-alpha alone induced significant release of MCP-1, IL-6 and SCF but in combination with IL-4 or IL-13 it induced greater secretion of MCP-1, IL-6 and SCF
Krishnamoorthy et al., Nat Med 2008 (Asthma) : This dual upregulation of c-Kit and SCF results in sustained signaling downstream of c-Kit, promoting IL-6 secretion
Erickson-Miller et al., Stem Cells 1993 : On the other hand, SCF increased the number of megakaryocytes per colony in the presence of IL-3, GM-CSF or IL-6
Jacobsen et al., Exp Hematol 1994 : While IL-1 or IL-6 had no proliferative effects as single growth factors, IL-1, in combination with granulocyte-macrophage CSF (GM-CSF), IL-3, CSF-1, and SCF, but not granulocyte-CSF (G-CSF), enhanced the cloning frequency of Lin-Sca-1+ progenitors three- to five-fold, whereas IL-6 increased the cloning frequency in response to all four CSFs and SCF two- to seven-fold
Rougier et al., Cytokine 1998 : IL-1 alpha, IL-1 beta, and IL-3, tumour necrosis factor alpha (TNF-alpha), Stem cell factor (SCF) and granulocyte-macrophage colony stimulating factor ( GM-CSF ) ( at 10 ng/ml ) stimulated IL-6 and IL-8 production in 0 % and 10 % FCS