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PRKCA — PTGS2

Text-mined interactions from Literome

Hsueh et al., Cancer Chemother Pharmacol 2000 : Protein expression of COX-2 and Bcl-2 and activation of PKCalpha were examined by Western blot analysis
Giroux et al., J Immunol 2000 : In this study, we addressed the role of PKC-alpha in the modulation of COX-2 expression and PGE2 synthesis by the overexpressing of a dominant negative ( DN ) mutant of this isoenzyme in the mouse macrophage cell line RAW 264.7 ... Taken together, these results suggest a role for PKC-alpha in the modulation of LPS- and IFN-gamma induced COX-2 expression, as well as in IFN-gamma induced PGE2 secretion
Wang et al., Mol Pharmacol 2001 (Inflammation) : In summary, our results indicate that epidermal PKC alpha coordinately regulates cPLA(2) activity and COX-2 expression resulting in increased levels of AA and PGE ( 2 ) ... Furthermore, PKC alpha induced AA release and cPLA(2) phosphorylation are independent of MEK, whereas PKC alpha induced COX-2 expression and PGE ( 2 ) production are MEK dependent and C/EBP beta independent events
Chang et al., Br J Pharmacol 2002 : These results indicate that in human pulmonary epithelial cells, YC-1 might activate PKG through an upstream sGC/cGMP pathway to elicit PKC-alpha activation, which in turn, initiates p44/42 MAPK activation, and finally induces COX-2 expression
Scoditti et al., Cardiovasc Res 2010 : As both protein kinase C (PKC)alpha and beta are involved in VEGF induced COX-2 expression and CREB activation, we investigated which isoform ( s ) of PKC was affected by RSG ... The anti-angiogenic effect of PPARgamma agonists is due, at least in part, to an interference with the VEGF stimulated PKCalpha mediated activation of CREB and the related expression of COX-2