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LEP — PTGS2

Text-mined interactions from Literome

Fain et al., Metabolism 2001 (Obesity) : These data suggest that when upregulation of COX-2 is blocked by dexamethasone, exogenous PGE ( 2 ) enhances both leptin release and leptin mRNA accumulation by explants of human adipose tissue in primary culture
Fain et al., Prostaglandins Leukot Essent Fatty Acids 2002 (MAP Kinase Signaling System) : Dexamethasone enhanced leptin release by adipocytes while inhibiting PGE ( 2 ) release and COX-2 up-regulation
Inoue et al., Eur J Neurosci 2006 (Inflammation) : Leptin induces cyclooxygenase-2 via an interaction with interleukin-1beta in the rat brain ... Coinjection of IL-1 receptor antagonist ( 100 microg/rat, intracerebroventricular ) attenuated leptin induced COX-2, whereas IL-1 receptor antagonist had no effect on endogenous IL-1beta levels, suggesting that leptin induces COX-2 via, at least partly, IL-1beta action
Beales et al., Mol Cell Endocrinol 2007 (Adenocarcinoma...) : The COX-2 inhibitor NS 398 blocked the effects of acid and leptin but while both acid and leptin individually significantly increased PGE2 production and COX-2 mRNA levels, the combination was not more effective than either stimulant alone
Gao et al., Cancer Sci 2009 (Endometrial Neoplasms) : Leptin induces functional activation of cyclooxygenase-2 through JAK2/STAT3, MAPK/ERK, and PI3K/AKT pathways in human endometrial cancer cells ... We also showed that leptin stimulated cell proliferation and induced activations of signal transducers and activators of transcription 3 ( STAT3 ), extracellular signal regulated kinase ( ERK1/2 ), AKT, and cyclooxygenase (COX)-2 in endometrial cancer cells dose-dependently by [ ( 3 ) H ] thymidine incorporation assay and western blotting ... Leptin induced functional activation of COX-2 is JAK2/STAT3-, MAPK/ERK-, and PI3K/AKT dependent, indicating that COX-2 may be a critical factor of endometrial carcinogenesis in obesity
Garonna et al., PloS one 2011 : Inhibition of VEGFR2 tyrosine kinase activity reduced leptin stimulated p38 ( MAPK ) and Akt activation, COX-2 induction , and pro-angiogenic EC responses, and blockade of VEGFR2 or COX-2 activities abolished leptin-driven neo-angiogenesis in a chick chorioallantoic membrane vascularisation assay in vivo ... These studies identify a new function for VEGFR2 as a mediator of leptin stimulated COX-2 expression and angiogenesis and have implications for understanding leptin 's regulation of the vasculature in both non-obese and obese individuals ... Immunoblotting studies showed that leptin increased cyclo-oxygenase-2 (COX-2) expression ( but not COX-1 ) in cultured human umbilical vein ECs ( HUVEC ) through pathways that depend upon activation of both p38 mitogen activated protein kinase ( p38 ( MAPK ) ) and Akt, and stimulated rapid phosphorylation of vascular endothelial growth factor receptor 2 ( VEGFR2 ) on Tyr ( 1175 )