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HPGD — PTGS2

Text-mined interactions from Literome

Tong et al., Carcinogenesis 2006 (Adenocarcinoma...) : This was further supported by the observation that overexpression of COX-2 but not COX-1 by adenovirus mediated approach led to a decrease in 15-PGDH expression, indicating the specificity of COX-2 ... However, overexpression of 15-PGDH by transfection with recombinant plasmid encoding 15-PGDH or adenovirus mediated approach attenuated IL-1beta induced expression of COX-2 ... On the contrary, downregulation of 15-PGDH expression by 15-PGDH-siRNA or 15-PGDH-antisense approach resulted in an increase in IL-1beta induced expression of COX-2 but not that of COX-1
Tai et al., Prostaglandins Other Lipid Mediat 2007 (Lung Neoplasms) : Over-expression of COX-2 but not COX-1 by adenoviral mediated approach also attenuated 15-PGDH expression ... Similarly, over-expression of 15-PGDH by the same strategy inhibited IL-1beta induced COX-2 expression
Yao et al., American journal of physiology. Renal physiology 2008 : In MMDD1 cells, a COX-2 inhibitor increased 15-PGDH , whereas a COX-1 inhibitor had no effect
Liu et al., Carcinogenesis 2008 (Adenocarcinoma...) : To further explore whether the 15-PGDH is regulated by COX-2 , western blotting and immunocytochemical assay were performed to detect the expression of 15-PGDH in different cell lines with different expression level of COX-2
Judson et al., Cancer prevention research (Philadelphia, Pa.) 2010 : Here too, COX-2 levels were induced and 15-PGDH levels suppressed following UVR exposure