Horikawa et al., Drug Metab Pharmacokinet 2003
:
However, cloxacillin, cyclosporin A and midecamycin inhibited BSEP , and cyclosporin A and midecamycin inhibited MRP2 with an inhibition constant close to the clinical concentration
Fickert et al., Am J Pathol 2007
(Cholangitis, Sclerosing...) :
Expression of Ntcp, Oatp4, and Mrp2 was significantly reduced, whereas Bsep expression remained unchanged and adaptive Mrp3 and Mrp4 expression was significantly induced