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ELN — TNF

Text-mined interactions from Literome

Starcher et al., Br J Dermatol 2000 (Cell Transformation, Neoplastic...) : These studies suggest that TNF-alpha plays no part in the accumulation of excessive elastin in the skin during chronic UVB exposure
Kähäri et al., J Biol Chem 1992 : The down-regulatory effect of TNF-alpha on elastin promoter activity was abolished by co-transfections with a synthetic double stranded AP-1 oligomer ... These observations suggest that the inhibitory effects of TNF-alpha on elastin gene expression involve the transcription factor AP-1
John et al., J Orthop Res 2010 : In response to TNFalpha , tenocytes reduced their type I collagen deposition but increased their elastin gene expression and highly upregulated their expression for MMP-1, pro-inflammatory ( TNFalpha, IL-1beta ) and immunoregulatory ( IL-6, IL-10 ) cytokines
Rédini et al., Biochem Biophys Res Commun 1988 : Tumor Necrosis Factor-alpha (TNF-alpha) and Interferon-gamma (IFN-gamma) significantly enhanced the elastin degrading activity present in the culture media of both synoviocytes and chondrocytes
Kochevar et al., J Invest Dermatol 1994 : These results suggest that excess TNF-alpha ( or other mediator ) produced in C3H/HeN skin ( but not C3H/HeJ skin ) in response to UVB exposure is involved in the mast cell increase and partial inhibition of elastin increase, but that neither these mediators nor mast cell products are important mediators for the chronic UVB induced increases in neutrophils, glycosaminoglycans, and collagen