Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
Complex of BCAR1-PTK2-TNS3
→
EGF
(decreases, BCAR1/PTK2/TNS3 Activity)
Cui et al., Mol Cancer Res 2004* Evidence: Furthermore, tensin3 forms a complex with focal adhesion kinase and p130Cas in MDA-MB-468 cells. Addition of EGF to the cells induces dephosphorylation of these two molecules, leads to disassociation of the tensin3-focal adhesion kinase-p130Cas complex, and enhances the interaction between tensin3 and EGF receptor.
BioCarta erk and pi-3 kinase are necessary for collagen binding in corneal epithelia:
ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin (active1)/p130cas/FAK/CSK/Paxillin/Vinculin/alp complex (ITGA1-PTK2-BCAR1-ACTN3_ACTN2_ACTN1_ACTN4-ZYX-TLN1-ITGB1-VCL-PXN-CSK-ACTA1-TNS1-CAPN1)
→
ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN)
(actin filament polymerization, collaborate)
BioCarta erk and pi-3 kinase are necessary for collagen binding in corneal epithelia:
ECM/Integrin-alpha/Integrin-betaTalin/Calpain1/actin/p130cas/FAK/CSK/Paxillin/Vinculin/alpha-actinin complex (ACTA1-VCL-ITGB1-ZYX-TNS1-CSK-CAPN1-ITGA1-ACTN3_ACTN2_ACTN1_ACTN4-PTK2-BCAR1-TLN1-PXN)
→
PIP2/Gelsolin complex (GSN)
(actin filament polymerization, collaborate)