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HMOX1 — INS

Text-mined interactions from Literome

Harrison et al., FEBS J 2006 (Adenocarcinoma...) : Insulin induces heme oxygenase-1 through the phosphatidylinositol 3-kinase/Akt pathway and the Nrf2 transcription factor in renal cells ... Following treatment with insulin, a five-fold increase in heme oxygenase-1 mRNA and a four-fold increase in protein expression were observed in renal adenocarcinoma cells ; insulin induced heme oxygenase-1 expression was also demonstrated in mouse primary tubular epithelial cells ... Pretreatment with NF-E2 related factor-2 small interfering RNA abolished insulin induced heme oxygenase-1 induction ... Insulin was also found to activate the mitogen activated protein kinase cascades p38 and extracellular signal related kinase ; however, inhibition of these pathways with SB202190 and PD98059 did not alter insulin induced heme oxygenase-1 expression
Li et al., Zhonghua Yi Xue Za Zhi 2006 (Cadaver) : Transfection of Ad-HO-1 into human islets improves anti-apoptotic function in cultured human islets and promotes insulin release of human pancreatic islets
Geraldes et al., J Biol Chem 2008 : Using HO-1 promoter analysis, the luciferase reporter assay showed that induction of HO-1 expression by insulin is mediated by additional response elements in the ho-1 promoter gene, which was not responsive to antioxidants ... Insulin induced HO-1 mRNA expression through activation of PI3-kinase/Akt pathway without affecting ERK and p38 MAPK ... Overexpression of an adenoviral vector of native IRS1, IRS2, and Akt dominant negative or small interfering RNA transfection of Akt1 and Akt2 targeted gene demonstrated that insulin regulated HO-1 expression via IRS1 and Akt2 pathway, selectively
Abdel Aziz et al., Angiology 2010 : We evaluated the effect of curcumin on isolated islets of Langerhans and studied whether its action on insulin secretion is mediated by inducible HO-1