Donahue et al., Eur J Immunol 2007
:
In contrast, LPS induced mTOR signaling is strikingly resistant to wortmannin in both subsets
Lorne et al., Am J Respir Cell Mol Biol 2009
(Acute Lung Injury) :
Rapamycin pretreatment inhibited PAM- or LPS induced mTORC1 activation in the lungs
Lee et al., PloS one 2010
(Endotoxemia) :
Furthermore, in vitro cellular studies demonstrated that LPS ( lipopolysaccharide ) activation of mTORC1-S6K still occurs in the presence of PI3K-Akt inhibition alone, but can be suppressed by concurrent inhibition of PI3K-Akt and MEK-ERK pathways