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IRF6 — NOS3

Text-mined interactions from Literome

Greenberg et al., Alcohol 1999 : Ethanol metabolism is not required for inhibition of LPS stimulated transcription of inducible nitric oxide synthase
Wanner et al., Langenbecks Arch Surg 1999 (Endotoxemia) : To further clarify the underlying mechanisms, rG-CSF treated liver cells were tested for the LPS induced gene expression of cytokine induced neutrophil chemoattractant ( CINC ) and intercellular adhesion molecule-1 ( ICAM-1 ) as potential chemotactic and leukocyte recruiting factors and for the gene expression of inducible nitric oxide synthase ( NOS II ) as potential modulator of leukocyte adherence
Paik et al., J Biol Chem 2000 (Adenocarcinoma...) : Flufenamic acid and 15-deoxy-Delta ( 12,14 ) -prostaglandin J ( 2 ) also inhibit LPS induced expression of inducible form of nitric-oxide synthase and interleukin-1alpha in RAW 264.7 cells
Morikawa et al., Infect Immun 2000 : The differential regulation of cNOS- and iNOS mediated NO production by IFN-gamma, TNF-alpha, and LPS is discussed
Lomniczi et al., Neuroimmunomodulation 2000 : There was no effect of either LPS or MB on the Ca ( 2+ ) -dependent constitutive NOS activity
Guo et al., Acta Pharmacol Sin 2000 : However, no marked difference was observed in the LPS induced NO production and the expression of iNOS and ecNOS between NG- and Mann-BAEC
Heiss et al., J Biol Chem 2001 : Western blot analyses revealed time- and dose dependent reduction of LPS induced inducible nitric-oxide synthase as well as Cox-2 protein expression, which was suppressed at the transcriptional level
Matsuzaki et al., J Nutr 2001 : The LPS induced expression of inducible nitric oxide synthase in the liver was significantly suppressed by the energy restriction
Kizaki et al., Biochem Biophys Res Commun 2001 : Negative regulation of LPS stimulated expression of inducible nitric oxide synthase by AP-1 in macrophage cell line J774A.1
Evdokimova et al., Toxicol In Vitro 2002 : Nitrites formation was used as an indirect way to assess LPS mediated activation of nitric oxide synthase ( iNOS, type 2 )
Baveja et al., Shock 2002 (Endotoxemia...) : eNOS mRNA levels did not increase in response to either BDL or LPS or a combination of both compared to sham
Helmer et al., Gastroenterology 2002 (Endotoxemia) : Lipopolysaccharide (LPS) enhanced the expression and activity of inducible nitric oxide synthase in gastric mucosa in a dose- and time dependent manner
Plum et al., Nephron 2002 (Peritonitis) : Prostacyclin enhances the expression of LPS/INF-gamma induced nitric oxide synthase in human monocytes
Li et al., Respir Res 2002 : Activation of macrophage nuclear factor-kappa B and induction of inducible nitric oxide synthase by LPS
Chano et al., Eur J Immunol 2002 : We have previously shown that overexpression of a dominant negative ( DN ) mutant of protein kinase C-alpha (PKC-alpha) in RAW 264.7 macrophages inhibited lipopolysaccharide (LPS) induced IL-1alpha, inducible nitric oxide synthase and cyclooxygenase-2 expression
Hsiao et al., Biochem Pharmacol 2003 (Shock, Septic) : A novel antioxidant, octyl caffeate, suppression of LPS/IFN-gamma induced inducible nitric oxide synthase gene expression in rat aortic smooth muscle cells
Kristof et al., J Biol Chem 2003 (Inflammation) : The role of mTOR and PI3K in the activation of human inducible nitric oxide synthase transcription by cytokines and lipopolysaccharide (LPS) was investigated in lung epithelial adenocarcinoma ( A549 ) cells ... LY294002, a dual mTOR and PI3K inhibitor, blocked human inducible nitric oxide synthase ( hiNOS ) promoter activation and mRNA induction by cytokines and LPS in a PI3K independent fashion
Hortelano et al., J Biol Chem 1992 : Incubation of cells with alpha-phorbol 12,13-didecanoate failed to counteract the effect of LPS or to induce nitric oxide synthase , suggesting that activation of protein kinase C was involved in this process
Peng et al., Chin Med J (Engl) 2003 : Both H ( 2 ) O ( 2 ) and LPS significantly increased the eNOS transcript levels and the increases were significantly attenuated after pretreatment with propofol ... Both H ( 2 ) O ( 2 ) and LPS significantly increased the eNOS protein expression and the increase was attenuated after pretreatment with propofol
Lee et al., Neurosci Lett 2003 (Brain Ischemia...) : Cell death was inhibited when the slice was co-treated with both LPS and N-monomethyl-L-arginine, a nitric oxide synthase inhibitor
Mitchell et al., Mol Pharmacol 1992 : Lipopolysaccharide (LPS) , either alone or in combination with cytokines, induces nitric oxide ( NO ) synthase activity in cells that normally release little or no NO
Suuronen et al., J Neurochem 2003 (Inflammation) : TSA clearly potentiated the LPS induced expression of interleukin (IL)-6 and inducible nitric oxide synthase mRNAs, as well as the secretion of cytokines IL-6, tumour necrosis factor-alpha and macrophage inflammatory protein (MIP)-2, and nitric oxide ( NO )
Brock et al., Prostaglandins Other Lipid Mediat 2003 : In addition to COX-2, nitric oxide synthase (NOS) was also induced by LPS
Lee et al., Biochem Pharmacol 2003 : Similarly, these compounds also suppressed the LPS induced inducible nitric oxide synthase expression and nitric oxide production
Wang et al., J Pharmacol Exp Ther 2004 (Inflammation...) : Furthermore, ANDRO dose-dependently attenuated LPS induced inducible nitric-oxide synthase and cyclooxygenase-2 protein expression in BV-2 microglia, as determined by Western blot
Giri et al., J Neurosci 2004 (Inflammation) : A pharmacological activator of AMPK, 5-amino-4-imidazole carboxamide riboside ( AICAR ) inhibited lipopolysaccharide (LPS) induced expression of proinflammatory cytokines ( tumor necrosis factor alpha, interleukin-1beta, and interleukin-6 ) and inducible nitric oxide synthase in primary rat astrocytes, microglia, and peritoneal macrophages
Wideman et al., Poult Sci 2004 (Hypertension, Pulmonary...) : LPS induces the expression of nitric oxide synthase ( iNOS ), which produces the vasodilator nitric oxide ( NO ) to modulate the responses to concurrently produced vasoconstrictors
Vega et al., J Leukoc Biol 2004 : This report focuses on the modulatory role of endogenous H ( 2 ) O ( 2 ) on lipopolysaccharide (LPS)/interferon-gamma (IFN-gamma) induced inducible nitric oxide synthase ( NOS2 ) gene expression in rat peritoneal macrophages
Kang et al., J Pharmacol Exp Ther 2004 (Cystitis...) : Increases in urinary cyclic GMP, NOS activity, and eNOS protein and phosphorylation 1 h after induction of inflammation with LPS , indicate that eNOS plays a role in the early response to bladder inflammation
Wideman et al., Poult Sci 2004 (Hypertension, Pulmonary...) : Previous in vitro studies conducted using macrophages from different lines of chickens demonstrated innate variability in the LPS stimulated induction of nitric oxide synthase ( iNOS ) followed by the onset of an LPS-refractory state
Elferink et al., Am J Physiol Gastrointest Liver Physiol 2004 (Drug-Induced Liver Injury) : In liver slices from both species, LPS induced expression of inducible nitric oxide synthase was detected within 1-3 h and remained increased over 24 h
Kim et al., Neuropharmacology 2004 : In this study, we found that a new compound KL-1037 suppressed LPS induced NO release/inducible nitric oxide synthase expression in BV2 mouse microglial cells
Shin et al., FEBS Lett 2004 (Inflammation) : Furthermore, the compound inhibited not only LPS induced expressions of tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6 and inducible nitric oxide synthase and cyclooxygenase-2 but also LPS induced apoptosis of the RAW 264.7 cells
Nakajima et al., J Biol Chem 2004 (Inflammation) : PARP-1 inhibitors and the antisense RNA for PARP-1 mRNA suppressed lipopolysaccharide (LPS) induced expression of tumor necrosis factor-alpha and inducible nitric-oxide synthase , suggesting that PARP-1 activity has a critical role in synthesis
Cho et al., Int Immunopharmacol 2004 : Previously, we showed that arctigenin potently inhibited the induction of nitric oxide synthase ( iNOS ) by lipopolysaccharide (LPS) , which involved suppression of NF-kappaB activation
Paintlia et al., J Neurosci Res 2004 (Demyelinating Diseases...) : Intraperitoneal pretreatment of pregnant female rats with NAC ( 50 mg/kg ), 2 hr prior to administration of LPS at embryonic day 18 ( E18 ), attenuated the LPS induced expression of inflammatory cytokines such as tumor necrosis factor-alpha, interleukin-1beta, and inducible nitric oxide synthase in fetal rat brains
Lee et al., J Biol Chem 2004 (Inflammation) : We found that TGase 2 activates the transcriptional activator nuclear factor (NF)-kappaB and thereby enhances LPS induced expression of inducible nitric-oxide synthase
Connelly et al., J Biol Chem 2005 (Inflammation...) : Furthermore, in human umbilical vein endothelial cells, LPS leads to the activation of eNOS through phosphoinositide 3-kinase- and Akt/protein kinase B-dependent enzyme phosphorylation
Kim et al., Biochem Biophys Res Commun 2005 : Protein expression of inducible nitric oxide synthase and cyclooxygenase-2, and production of NO by these cells were induced by LPS or IFN-gamma
Merkel et al., Microcirculation 2005 (Inflammation) : LPS inhibits endothelin-1 mediated eNOS translocation to the cell membrane in sinusoidal endothelial cells ... These studies demonstrate an LPS mediated uncoupling of endothelin receptor activation and eNOS translocation
Lee et al., J Pharmacol Exp Ther 2006 : LPS induced production of TNF-alpha and NO as well as expression of inducible nitric-oxide synthase and cyclooxygenase-2 was significantly suppressed by the treatment of cardamomin in RAW264.7 cells
Martin et al., J Pharmacol Exp Ther 2006 : Similar inhibition by A ( 3 ) AR was observed for LPS stimulated inducible nitric-oxide synthase
Karaa et al., Shock 2005 (Body Weight...) : Combined, LPS and chronic ethanol feeding showed a synergistic effect on the liver, leading to extensive steatohepatitis with extensive focal necrosis associated with significantly higher levels of serum ALT. Chronic ethanol and LPS significantly inhibited eNOS activity, but exerted their effects through different mechanisms
Nakaya et al., Biochem Pharmacol 2005 : Isoflavone genistein and daidzein up-regulate LPS induced inducible nitric oxide synthase activity through estrogen receptor pathway in RAW264.7 cells
Saito et al., J Pharmacol Sci 2005 : The purpose of this study was to investigate the effects of daunorubicin on lipopolysaccharide (LPS) stimulated inducible-type nitric oxide synthase ( iNOS ) expression in macrophages
Kamoun et al., Hepatology 2006 : LPS inhibits endothelin-1 induced endothelial NOS activation in hepatic sinusoidal cells through a negative feedback involving caveolin-1 ... Our aim was to assess the effects of LPS on ET-1 mediated eNOS activation in hepatic sinusoidal endothelial cells ( SECs ) and to investigate the molecular mechanisms involved ... LPS significantly inhibited ET-1 mediated eNOS activation ... In conclusion, LPS induced suppression of ET-1 mediated eNOS activation is ET-1 dependent and suggest a pivotal role of CAV-1 in eNOS induction inhibition under stress
Kim et al., Planta Med 2006 : Luteolin inhibits LPS stimulated inducible nitric oxide synthase expression in BV-2 microglial cells
Kim et al., Biochem Biophys Res Commun 2006 (Inflammation) : It also decreases LPS induced expression of inducible nitric oxide synthase and production of nitric oxide, and reduces LPS induced secretion of tumor necrosis factor-alpha and monocyte chemoattractant protein-1
Suh et al., Am J Respir Cell Mol Biol 2006 : CO also decreased LPS induced nitric oxide synthase-2 protein expression and nitrite production, and decreased LPS induced activation of protein binding to C/EBP consensus oligonucleotides of murine nitric oxide synthase-2 promoter
Munger et al., Am J Physiol Regul Integr Comp Physiol 2006 : Acute renal response to LPS : impaired arginine production and inducible nitric oxide synthase activity
Mohammad et al., Int Immunol 2006 (Diabetes Mellitus, Experimental) : Dysregulation of TLR4 expression in the diabetic state correlated with increased nuclear factor kappa B (NF-kappaB) activation in response to the TLR4 ligand LPS and higher expression of IL-12p40, tumor necrosis factor alpha (TNFalpha), IL-6 and inducible nitric oxide synthase but lowered expression of IL-10
Persichini et al., Antioxid Redox Signal 2006 : In addition, the results of recent studies are summarized, suggesting possible mechanisms whereby LPS and/or proinflammatory cytokines may cause inhibition of cNOS
Naureckiene et al., J Pharmacol Toxicol Methods 2007 : We also demonstrate that LPS stimulation of the mouse macrophage cell line RAW 264.7 induces the expression of iNOS, but not nNOS or eNOS , at the levels of mRNA transcription and protein expression
Sunday et al., Am J Physiol Heart Circ Physiol 2007 (Vasculitis, Central Nervous System) : In 4-mo-old rats, estrogen also significantly suppressed LPS induction of inducible nitric oxide synthase and cyclooxygenase-2 proteins, as well as production of nitric oxide and PGE ( 2 )
Skorokhod et al., Malaria journal 2007 (Malaria) : Malarial pigment haemozoin, IFN-gamma, TNF-alpha, IL-1beta and LPS do not stimulate expression of inducible nitric oxide synthase and production of nitric oxide in immuno purified human monocytes
Arai et al., Acta Otolaryngol 2008 : Induction of inducible nitric oxide synthase and apoptosis by LPS and TNF-alpha in nasal microvascular endothelial cells
Doursout et al., Shock 2008 (Cardiomyopathies...) : LPS also induced increases in eNOS in the heart and lungs, whereas iNOS was mostly detected in the liver
Thabut et al., Hepatology 2007 (Disease Models, Animal...) : Therefore, the aim of this study was to assess the effects of reconstituted high-density lipoprotein ( rHDL ) administration on the LPS induced proinflammatory response, intrahepatic eNOS regulation, and portal hypertension in cirrhotic rats
Malyshev et al., J Gastroenterol Hepatol 2007 (Liver Cirrhosis) : The results of this study may explain the worsening of the hyperdynamic state in cirrhosis during septic shock by direct LPS induced eNOS activation in large systemic vessels, and its inhibition in concomitant small splanchnic vasculature by iNOS synthesized NO
McMaster et al., Br J Pharmacol 2008 : Cigarette smoke extract also inhibited nitric oxide synthase II protein expression in response to LPS
Kim et al., J Microbiol Biotechnol 2007 : LADI dose-dependently inhibited lipopolysaccharide (LPS) induced upregulation of inducible nitric oxide synthase and the production of nitric oxide in RAW 264.7 murine macrophages
Liang et al., J Biol Chem 2008 (Inflammation) : Further studies demonstrated that MCPIP1 did not directly affect the mRNA stability of tumor necrosis factor alpha and monocyte chemoattractant protein 1 ( MCP-1 ) but strongly inhibited LPS induced tumor necrosis factor alpha and inducible nitric-oxide synthase promoter activation
Kizaki et al., Immunology 2008 : Both LPS stimulated inducible nitric oxide synthase ( NOS II ) expression and NO production were markedly suppressed in the RAWar cells
Begum et al., J Pharmacol Exp Ther 2008 (Alzheimer Disease...) : Despite dramatically higher drug plasma levels after TC compared with curcumin gavage, resulting brain levels of parent compounds were similar, correlating with reduction in LPS stimulated inducible nitric-oxide synthase , nitrotyrosine, F2 isoprostanes, and carbonyls
Liu et al., FEBS Lett 2008 (Shock, Septic) : In the present study, we found that PTS2 dose-dependently inhibited the LPS induced up-regulation of nitric oxide synthase ( iNOS ) and cyclooxygenase-2 (COX-2) protein level in RAW264.7 cells
Lee et al., Biochim Biophys Acta 2008 (Neoplasms...) : In addition, IRF-1 directly inhibited the tube formation of endothelial cells on Matrigel and reduced the expression of p-Akt, and p-eNOS , which play a significant role in angiogenesis when stimulated by VEGF
Shi et al., Blood 2008 (Gram-Negative Bacterial Infections...) : Furthermore, rTMD1 modulated LPS induced mitogen activated protein kinase and nuclear factor-kappaB signaling pathway activations and inducible nitric oxide synthase expression in macrophages
Kim et al., J Microbiol Biotechnol 2008 : MEH and MW also inhibited the LPS induced inducible nitric oxide synthase expression
Sande et al., Am J Pathol 2008 (Disease Models, Animal...) : In addition, melatonin significantly abrogated the LPS induced increase in retinal nitric-oxide synthase activity, tumor necrosis factor-alpha, and nuclear factor kappaB p50 and p65 subunit levels
Kim et al., Am J Physiol Gastrointest Liver Physiol 2009 (Disease Models, Animal...) : Liquiritigenin ( LQ ), an active component of licorice, has an inhibitory effect on LPS induced inhibitory nitric oxide synthase expression
Kallapur et al., Am J Respir Crit Care Med 2009 (Chorioamnionitis...) : rhIL-1ra decreased IA LPS induced lung inflammation assessed by decreased lung neutrophil and monocyte influx, inducible nitric oxide synthase expression, lung IL-6 and IL-1beta mRNA expression, and airway myeloperoxidase concentrations
Li et al., Free Radic Biol Med 2009 (Shock, Septic) : GYY4137 inhibited LPS induced TNF-alpha production in rat blood and reduced the LPS evoked rise in NF-kappaB activation, inducible nitric oxide synthase/cyclooxygenase-2 expression, and generation of PGE ( 2 ) and nitrate/nitrite in RAW 264.7 macrophages
Ward et al., Dig Dis Sci 2010 (Bile Reflux...) : In the rat, laparotomy, done either before or after administration of LPS, attenuated LPS induced bile reflux, gastric bleeding, and cyclooxygenase-2, but not inducible nitric oxide synthase , expression when compared to controls given LPS
Sánchez-Lemus et al., Brain Behav Immun 2009 (Inflammation) : The ARB reduced LPS induced pituitary gene expression of IL-6, LIF, iNOS, COX-2 and IkappaB-alpha ; and prevented LPS induced increase of nNOS/eNOS activity
Fleisher-Berkovich et al., Peptides 2009 (Inflammation) : The data shows that both carnosine and N-acetyl carnosine significantly attenuated the LPS induced nitric oxide synthesis and the expression of inducible nitric oxide synthase by 60 % and 70 %, respectively
Kim et al., Eur J Clin Invest 2009 (Edema) : Our in vitro experiments showed that celastrol suppressed not only LPS stimulated generation of nitric oxide and prostaglandin E ( 2 ), but also expression of inducible nitric oxide synthase and cyclooxygenase-2 in RAW264.7 cells
Ding et al., J Immunol 2009 (Shock, Septic...) : TNF-alpha knockout mice prevented LPS induced eNOS down-regulation
Kwok et al., Shock 2010 : Genetic deletion of Cav-1 increased basal eNOS activity ( 0.40 in KO vs. 0.15 fmol/min per well in WT ; +262 % ; P < 0.05 ) and reversed LPS inhibition of ET-1 stimulated eNOS activity ( +25.7 % ; P < 0.05 ) by increasing eNOS-Ser1177 ( +40.3 % ; P < 0.05 ) and decreasing eNOS-threonine-495 ( -8.8 % ; P < 0.05 ) phosphorylation
Gerhäuser et al., Mol Nutr Food Res 2009 : We further identified aroma compounds as potent inhibitors of LPS induced inducible nitric oxide synthase activity in Raw 264.7 cell culture
Chang et al., Inflammation 2010 (Inflammation) : GLA significantly inhibited LPS induced protein expression of inducible nitric oxide synthase , pro-interleukin-1beta, and cyclooxygenase-2 as well as nitric oxide production and the intracellular glutathione level
Huang et al., J Agric Food Chem 2009 : LPS induced cyclooxygenase-2 (COX-2) and nitric oxide synthase ( iNOS ) protein expression were both attenuated by P. vulgaris ethanol extracts, whereas RA inhibited only COX-2 expression
Lee et al., Int Immunopharmacol 2010 : In RAW264.7 macrophage cells, saurolactam significantly inhibited the lipopolysaccharide (LPS) induced expression of inducible nitric oxide synthase and cyclooxygenase-2 and, consequently, inhibited the release of NO and prostaglandin E2
Lee et al., Biochem Biophys Res Commun 2010 : Consistent with these findings, alpha-iso-cubebenol also reduced the LPS induced expression of inducible nitric oxide synthase and cyclooxygenase-2 at the protein and mRNA levels in a concentration dependent manner
Slomiany et al., Inflammopharmacology 2010 : The effect of ghrelin on the LPS induced changes in cNOS activity, moreover, was reflected in the increased cNOS phosphorylation that was sensitive to PP2 as well as SH-5
Hu et al., Transpl Immunol 2010 (Liver Diseases) : However, LPS accelerated activation of iNOS, but suppressed the expression of eNOS
Slomiany et al., Mediators Inflamm 2010 : Moreover, the effect of ghrelin on the LPS induced changes in cNOS activity was reflected in the increased cNOS phosphorylation that was sensitive to SH-5
Chu et al., Food Chem Toxicol 2010 (Acute Lung Injury...) : Further, sesamol significantly inhibited LPS induced TNF-alpha, nitrite, inducible nitric oxide synthase expression, and nuclear factor-kappaB activation levels in primary alveolar macrophages
Lin et al., Stroke 2010 (Hypoxia-Ischemia, Brain) : Upregulating endothelial nitric oxide synthase (eNOS) protects against cerebral ischemia ; however, whether eNOS is required for LPS preconditioning induced protection in neonatal rats is unknown ... LPS induced eNOS was expressed primarily in neurons and vascular endothelial cells
Shin et al., Int Immunopharmacol 2010 : Sulfuretin isolated from heartwood of Rhus verniciflua inhibits LPS induced inducible nitric oxide synthase , cyclooxygenase-2, and pro-inflammatory cytokines expression via the down-regulation of NF-kappaB in RAW 264.7 murine macrophage cells
Wu et al., J Sci Food Agric 2010 (Inflammation) : Ethanolic extracts from both stem and leaf of C. sativum ( CSEE ) significantly decreased LPS induced nitric oxide and prostaglandin E ( 2 ) production as well as inducible nitric oxide synthase , cyclooxygenase-2, and pro-interleukin-1beta expression
Hseu et al., Food Chem Toxicol 2010 : In an earlier study, we found that Antrodia camphorata inhibited the production of lipopolysaccharide (LPS) induced cytokines, inducible nitric oxide synthase , and cyclooxygenase-2 by blocking nuclear factor-kappaB (NF-kappaB) activation in cultured RAW 264.7 macrophages
Hsieh et al., J Biol Chem 2011 : Andrographolide was shown to suppress LPS/IFN-? induced inducible nitric-oxide synthase and matrix metalloprotease 9 expression in rat VSMCs. Andrographolide also inhibited LPS/IFN-? induced p65 nuclear translocation, DNA binding activity, p65 Ser ( 536 ) phosphorylation, and NF-?B reporter activity
Slomiany et al., Journal of signal transduction 2010 : We demonstrate that the detrimental effect of the LPS on cNOS was manifested by the enzyme protein S-nitrosylation, that was susceptible to inhibition by iNOS inhibitor, 1400?W
Valente et al., Neurobiol Aging 2012 (Amyotrophic Lateral Sclerosis...) : In this study we demonstrate that the expression of nitric oxide ( NO ) synthase-2 ( NOS2 ), and cyclooxygenase (COX)-2 induced by lipopolysaccharide (LPS) with interferon-? is higher in microglial enriched cultures from G93A-SOD1 mice, an ALS animal model, than from wild type mice
Mogilenko et al., FASEB J 2012 : We have shown that endogenous ApoA-I stabilizes ABCA1, moreover, down-regulation of ApoA-I by siRNA results in an increase of Toll-like receptor 4 (TLR4) mRNA and membrane surface protein expression, as well as an enhancement of bacterial lipopolysaccharide (LPS) induced expression of tumor necrosis factor-a (TNF-a), interleukin 1ß (IL-1ß), and inducible nitric oxide synthase ( NOS2 ) genes in human macrophages
Chinta et al., Parkinson's disease 2012 : DHB significantly attenuated LPS mediated induction of nitric oxide synthase and pro-inflammatory cytokines in murine BV2 microglial cells in vitro in conjunction with reduced ROS production and activation of NF?B and MAPK pathways possibly due to up-regulation of HO-1 levels
Yang et al., Mol Cell Biochem 2013 (Inflammation) : Treatment with AH inhibited lipopolysaccharide (LPS) induced interleukin-6, IL-1ß, inducible nitric oxide synthase , and cyclooxygenase-2 expression and nitric oxide production
Bai et al., J Surg Res 2013 (Acute Lung Injury...) : In addition, shikonin pretreatment significantly suppressed LPS induced activation of cyclooxygenase 2 and inducible nitric oxide synthase and the nuclear factor ?B DNA binding activity in lung tissues
Ro et al., Transplantation 2012 : Both polyriboinosinic polyribocytidylic acid and lipopolysaccharide (LPS) stimulation induced the mRNA expression of regulated and normal T cell expressed and secreted, interferon-?-inducible protein-10, monocyte chemotactic protein-1, interleukin-8, and inducible nitric oxide synthase in murine islets, whereas the induction was attenuated in TRIF-KO, interferon-ß promoter stimulator-1-KO, and TLR4-KO mice
Murakami et al., Biofactors 2013 (Colitis...) : Both CUR and ATM inhibited lipopolysaccharide (LPS) induced expression of inducible forms of both nitric oxide synthase and cyclooxygenase ( iNOS and COX-2, respectively )
Sinha et al., Chem Res Toxicol 2013 (Neoplasms) : LPS mediated induction of nitric oxide synthase in murine macrophages resulted in VP-16 resistance compared to Raw cells
Chiao et al., Clin Sci (Lond) 2013 : LPS induced plasma levels of IL-1ß, TNFa ( tumour necrosis factor a ), IL-10, vascular eNOS ( endothelial NOS ) and COX2 ( cyclo-oxygenase 2 ) protein expression, as determined by ELISA and Western blot, observed in WT mice were inhibited by IL1ra and in P2X7KO mice
Li et al., Mol Med Report 2013 (Acute Lung Injury...) : The upregulation of matrix metalloproteinase-9, interleukin (IL)-1ß, IL-6 and inducible nitric oxide synthase was induced by LPS in the mouse model of sepsis and the TC-1 cell line, and resveratrol suppressed the overexpression of these proinflammatory molecules in a dose-dependent manner
Baydoun et al., Br J Pharmacol 1993 : 1. Effects of dexamethasone on induction of nitric oxide ( NO ) synthase and L-arginine transport by lipopolysaccharide (LPS) were examined in a murine cultured macrophage cell line J774
Fujihara et al., J Immunol 1994 : Thus, PKC could be a part of the signal transduction apparatus involved in LPS induced inducible nitric oxide synthase gene activation
Chesrown et al., Biochem Biophys Res Commun 1994 : Regulation of inducible nitric oxide synthase mRNA levels by LPS , INF-gamma, TGF-beta, and IL-10 in murine macrophage cell lines and rat peritoneal macrophages
Sparrow et al., Exp Eye Res 1994 : Conversely, when transforming growth factor-beta was present in the culture medium, gamma-interferon-LPS induced expression of nitric oxide synthase and NO release were reduced
Paul et al., Br J Pharmacol 1995 : 1. In RAW 264.7 macrophages, lipopolysaccharide (LPS) and gamma-interferon ( IFN gamma ) alone or in combination stimulated the induction of nitric oxide synthase ( iNOS ) activity and increased the expression of the 130 kDa isoform of NOS ... 8. These results suggest the involvement of protein kinase C, tyrosine kinase and poly-ADP ribosylation pathways in the regulation of the induction of nitric oxide synthase in RAW 264.7 macrophages by LPS and IFN gamma
Hamilton et al., J Clin Invest 1995 : The cooperative effects of IFN gamma and LPS on the expression of the inducible nitric oxide synthase gene were suppressed by oxidized LDL while the antagonistic effect of IFN gamma on LPS induced expression of the TNF receptor type II mRNA was not altered
Parker et al., Shock 1994 (Toxemia) : Since L-NAME unmasked a vasoconstrictor action of the endogenous purinoceptor agonist ADP, pharmacologic agents that inhibit NOS may exacerbate LPS induced inhibition of endothelial NOS ; this series of events could lead to diminution of vasodilator reserves and perhaps to augmentation of platelet aggregation during Gram negative sepsis
Mustafa et al., Hepatology 1996 (Shock, Septic) : The current study indicates that exogenous PAF contributes to the induction of nitric oxide synthase by LPS in cultured rat Kupffer cells
Cirino et al., Br J Pharmacol 1996 : 1. The effects of novel nitric oxide releasing nonsteroidal anti-inflammatory compounds ( NO-NSAIDs ) on induction of nitric oxide ( NO ) synthase by bacterial lipopolysaccharide (LPS) were examined in a murine cultured macrophage cell line, J774
Eason et al., Arch Int Pharmacodyn Ther 1995 : These results provide strong evidence for the involvement of tyrosine kinases in the induction of nitric oxide synthase by LPS and IFN-gamma in J774 macrophages
Sorrells et al., Arch Surg 1996 : In addition, LPS upregulates inducible nitric oxide synthase expression in the intestinal epithelium-a phenomenon that can either enhance microbial killing, or alternatively, promote BT by impairing the gut barrier
Martin et al., Infect Immun 1997 : In gram negative septic shock, lipopolysaccharide (LPS) induces nitric oxide ( NO ) synthase , which contributes to the vascular hypotension and hyporeactivity to vasoconstrictors
Salkowski et al., Infect Immun 1997 : We compared the ability of LPS and MPL to induce interleukin-10 (IL-10), IL-12 p35, IL-12 p40, gamma interferon ( IFN-gamma ), glucocorticoid receptor ( GR ), IL-1 receptor antagonist (IL-1ra), and inducible nitric oxide synthase mRNA expression in murine peritoneal macrophages
Schwacha et al., J Leukoc Biol 1998 (Burns) : Inhibition of nitric oxide synthase activity with NG-monomethyl-L-arginine restored ConA responses but not LPS responses
Sastre et al., Biochem J 1998 : As expected, LPS dose-dependently stimulated the inducible nitric oxide synthase activity ( iNOS )
Tawara et al., J Neurosci Res 1998 (Glioma) : In addition, pretreatment of the cells with 100 nM dexamethasone for 24 hr significantly suppressed LPS induced inducible nitric oxide synthase ( iNOS ; type II NOS, NOS-II ) protein expression
Huang et al., Biochem Biophys Res Commun 1998 (Shock, Septic) : We found that the ecNOS activity is transiently enhanced by LPS within the time scale of about 10 h due to the interplay between two LPS induced mechanisms
Noda et al., Biol Pharm Bull 1998 : Defect in the induction of nitric oxide synthase by lipopolysaccharide (LPS) in an LPS-resistant mutant of a murine macrophage-like cell line, J774.1
Chang et al., Biochem Biophys Res Commun 1998 : Consistent with this finding, Northern blot analysis indicated that 25-OH-cholesterol potentiated the LPS induced nitric oxide synthase RNA levels
McKinney et al., J Leukoc Biol 1998 : Ionizing radiation potentiates the induction of nitric oxide synthase by IFN-gamma and/or LPS in murine macrophage cell lines : role of TNF-alpha
Gao et al., J Immunol 1998 : We have examined the role of Stat1alpha in the induction by LPS of the mouse inducible nitric oxide synthase ( EC 1.14.13.39 ) gene ... Collectively, these results show that LPS induced IFN-alphabeta production, Stat1alpha activation, and nitrite accumulation closely parallel one another, suggesting that indirect activation of transcription factor Stat1alpha by IFN-alphabeta is a critical determinant of LPS mediated inducible nitric oxide synthase gene expression
Closs et al., FASEB J 1998 (Diarrhea...) : LPS induces nitric oxide synthase II ( NOS II, inducible NOS ) in various types of cells
Lysle et al., J Pharmacol Exp Ther 1999 : In the present study, we tested the hypothesis that lipopolysaccharide (LPS) induced expression of nitric oxide synthase ( iNOS ) by splenocytes is modulated through the activation of endogenous opioids in the central nervous system