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HMOX1 — IRF6

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Kitamura et al., Neurosci Lett 1999 : However, PPARgamma activator alone induced HO-1 expression and further enhanced LPS/IFN-gamma induced HO-1 expression
Datta et al., Kidney Int 1999 : HO-1 expression was also increased in response to LPS/IFN-gamma
Alcaraz et al., Br J Pharmacol 2000 : 3. Our results indicate that reactive oxygen species participate in the inductive effect of NO donors or LPS on HO-1 expression, whereas endogenous NO production may play a role in the mechanism of the synergy exhibited by SPNO and LPS on HO-1 and COX-2 expression
Li et al., Sheng Li Xue Bao 2001 : The results demonstrate that LPS induces HO-1 mRNA expression of NRCMs dose- and time-dependently to some extent
Baveja et al., Shock 2002 (Endotoxemia...) : HO-1 expression increased significantly in sham + LPS , but failed to increase in BDL + LPS
Oguro et al., FEBS Lett 2002 : Induction of HO-1 by LPS is reported to be mediated through interleukin-1beta (IL-1beta), rather than other inflammatory cytokines in the mouse liver ... All of these findings indicate that TNFalpha is a major candidate to trigger HO-1 induction in response to LPS stimulation, and that its message is likely transduced through JNK and p38 pathways
Song et al., World J Gastroenterol 2003 : TLR4 mediates LPS induced HO-1 expression in mouse liver : role of TNF-alpha and IL-1beta ... Previous studies demonstrated that LPS induced HO-1 gene activation and HO-1 expression in liver ... However, the mechanisms of LPS induced HO-1 expression in liver remain unknown ... The effect of toll-like receptor-4 (TLR4) on LPS induced liver HO-1 expression and the role of TNF-alpha and IL-1beta in this condition were determined ... The present results confirm that macrophages are the major source of HO-1 in the liver induced by LPS ... LPS induced HO-1 expression is mainly mediated by endogenous TNF-alpha, but only partially by endogenous IL-1beta
Harvey et al., Am Surg 2004 (Systemic Inflammatory Response Syndrome) : An in vitro model of microvascular lung pericytes (MLP) was used to investigate the effect of inhibiting heme oxygenase-1 (HO-1) , a stress induced enzyme, in the presence of varying levels of lipopolysaccharide (LPS) , a mediator in the initiation of inflammation, on pericyte contractility
Lin et al., J Cell Physiol 2005 : Both HT and NE, but not their respective glycosides HD and NI, induced heme oxygenase 1 (HO-1) protein expression in the presence or absence of LPS and showed time and dose dependent inhibition of LPS induced nitric oxide ( NO ) production and inducible nitric oxide synthase (iNOS) expression in RAW264.7, J774A.1, and thioglycolate elicited peritoneal macrophages
Wijayanti et al., Antioxid Redox Signal 2004 (MAP Kinase Signaling System) : Here, it is shown that LPS induced the endogenous HO-1 gene expression in RAW264.7 monocytic cells ... To investigate the molecular mechanisms of HO-1 gene induction by LPS , we performed transfection experiments with reporter gene constructs containing sequences of the proximal rat HO-1 gene promoter ... Deletion and mutation analysis indicated that a cyclic AMP response element/activator protein-1 site ( -664/-657 ), but not an E-box motif ( -47/-42 ), played a major role for LPS dependent HO-1 gene induction ... Up-regulation of HO-1 promoter activity by LPS was decreased by pharmacological nuclear factor-kappaB (NF-kappaB) inhibitors and by cotransfected expression vectors with dominant negative isoforms of NF-kappaB inducing kinase, inhibitor of NF-kappaB (IkappaB) kinase beta, and IkappaBalpha ... Moreover, the p38 mitogen activated protein kinase ( MAPK ) inhibitor SB203580 and overexpressed dominant negative p38beta decreased, whereas dominant negative p38delta increased, LPS dependent induction of HO-1 gene expression ... The results suggest that the NF-kappaB and p38 MAPK signaling pathways mediate the LPS dependent induction of HO-1 gene expression via DNA sequences of the proximal promoter region
Dijkstra et al., J Pathol 2004 (Colonic Neoplasms...) : LPS induced iNOS but not HO-1 in epithelial cells of the ileum and colon
Chung et al., J Biol Chem 2005 (Inflammation) : Finally, overexpression of a dominant negative form of Ets-2 blunted HO-1 promoter induction by LPS , and kinase inhibitors ( PI3K more than JNK ) that reduced Ets-2 expression markedly decreased endogenous HO-1 expression ... Our data provide evidence that Ets-2 contributes to the up-regulation of HO-1 by the potent inflammatory stimulus LPS in macrophages
Szászi et al., Free Radic Biol Med 2005 : DEM plus LPS caused synergistic induction of heme oxygenase-1 (HO-1) , suggesting its role in the inhibitory effects of DEM
Romics et al., Alcohol Clin Exp Res 2005 (Disease Models, Animal...) : However, LPS induced HO-1 , but not iNOS, expression was attenuated in ob/ob compared with lean mice
Rushworth et al., J Immunol 2005 : At present, the role of Nrf2 in LPS induced HO-1 expression in monocytic cells has not been investigated ... Nrf2 translocated from the cytosol to the nucleus in response to LPS and bound to the ARE site in the human HO-1 promoter ... In addition, a dominant negative Nrf2 mutant inhibited LPS induced HO-1 mRNA expression but not TNF-alpha mRNA expression in THP-1 cells ... Ro-31-8220, a pan-protein kinase C ( PKC ) inhibitor, and Go6976, a classical PKC inhibitor, blunted LPS induced HO-1 mRNA expression in monocytes and THP-1 cells ... These results indicate that LPS induced HO-1 expression in human monocytic cells requires Nrf2 and PKC
Lee et al., Planta Med 2005 : PPD also induces heme oxygenase 1 (HO-1) expression in RAW 264.7 cells, at the mRNA and protein levels, in the presence and absence of LPS
Chung et al., J Immunol 2006 : Endotoxin administration to macrophages led to a dose dependent decrease in endogenous Elk-3 mRNA levels, and this reduction in Elk-3 preceded the LPS mediated up-regulation of HO-1 message
Chang et al., J Surg Res 2006 (Acute Disease...) : LPS caused prominent kidney and liver injuries as well as iNOS and HO-1 expression in stimulated rats ... In addition, the inhibition of iNOS expression by HBO pretreatment was associated with `` super-induction '' ( i.e., further enhancement ) of LPS induced HO-1 expression
Tracz et al., Am J Pathol 2007 (Inflammation) : Lipopolysaccharide (LPS) induces the stress-responsive gene heme oxygenase-1 (HO-1)
Tamion et al., Am J Physiol Gastrointest Liver Physiol 2007 (Disease Models, Animal...) : The aim of this study was to investigate the protective effect of PC against LPS induced systemic inflammatory and intestinal heme oxygenase-1 (HO-1) expression
Ashino et al., Mol Immunol 2008 : LPS ( 1 microg/mL ) maximally induced inducible nitric oxide synthase (iNOS) and HO-1 mRNAs in wild-type ( WT ) macrophages at 6h and 12h after treatment, respectively, and liberated tumor necrosis factor alpha (TNFalpha) from WT macrophages ... LPS also induced iNOS and HO-1 in TNFalpha ( -/- ) macrophages, but not in iNOS ( -/- ) macrophages
Adams et al., Dig Dis Sci 2009 (Drug-Induced Liver Injury) : In fasted rats, LPS significantly increased serum aminotransferase levels, enhanced hepatic COX2, iNOS, and HO1 immunoreactivity, and increased serum cytokine levels when compared to controls
Ito et al., Biogerontology 2009 (Acute Lung Injury...) : LPS induced HO-1 upregulation was significantly impaired in the lungs of 65-66-week-old mice than in 9-11-week-old mice at 2 and 24 h, although there were no differences in the magnitude of HO-1 upregulation in bronchiolar epithelium at 2 h. LPS induced upregulation of HO-1 was observed in AMs from 22-week-old mice ( 1.8-fold ), but not in AMs from 86-96-week-old mice in vitro ... In summary, we demonstrated age related defects in HO-1 induction in the whole lungs and in AMs in response to LPS
Naidu et al., J Immunol 2008 : In this study it is reported that the HO-1 gene is transcriptionally induced by the phorbol ester PMA in cell cultures of monocytic cells with a regulatory pattern that is different from that of LPS dependent HO-1 induction in these cells
Rushworth et al., J Immunol 2008 (Inflammation...) : These results show for the first time that LPS induces NQO1 and HO-1 expression in human monocytes via Nrf2 to modulate their inflammatory responsiveness, thus providing novel potential therapeutic strategies for the treatment of sepsis
Tzima et al., J Exp Med 2009 (Listeriosis) : We demonstrate that myeloid HO-1 is required for the activation of interferon ( IFN ) regulatory factor ( IRF) 3 after Toll-like receptor 3 or 4 stimulation, or viral infection
Kamimoto et al., Int J Mol Med 2009 (Acute Disease...) : In the culture of macrophages ( Raw264.7 ), HGF enhanced the LPS mediated HO-1 induction, and this effect was abolished by cycloheximide, but not by actinomycin-D, thus suggesting that a post-transcriptional pathway is involved in HGF mediated up-regulation of HO-1
Jeong et al., Int Immunopharmacol 2009 (Dental Plaque...) : Incubation of hPDL cells with apigenin decreased LPS- and nicotine induced HO-1 protein expression and activity
Kim et al., J Periodontol 2009 : Proinflammatory cytokines and LPS triggered iNOS and HO-1 expression and NO production in PDL cells ... HO-1 inhibitor and HO-1 small interfering RNA ( siRNA ) attenuated the LPS- and cytokine stimulated NO release and iNOS and HO-1 expression ... Specific inhibitors of p38, extracellular signal regulated kinase ( ERK ), and c-Jun N-terminal kinase (JNK) mitogen activated protein kinases phosphatidylinositol 3-kinase (PI3K), nuclear factor-kappa B (NF-kappaB), and protein kinase C delta (PKC-delta) greatly reduced the levels of iNOS and HO-1 expression induced by LPS plus cytokines ... Collectively, these data suggested that HO-1 inhibition blocked LPS- and proinflammatory cytokine stimulated iNOS expression and NO production in PDL cells via a mechanism that involves p38, ERK, PI3K, NF-kappaB, and PKC-delta
Liu et al., Cell Mol Life Sci 2010 : LPS stimulated transcriptional activation of HO-1 via an increase in PPAR-gamma DNA binding activity, which was reversed by IL-13
Jung et al., Biochem Pharmacol 2010 : Moreover, LPS induced HO-1 expression was mediated by an NF-kappaB dependent pathway
Zhao et al., Zhongguo Ying Yong Sheng Li Xue Za Zhi 2006 (Shock, Septic) : The role of activated nuclear factor-kappa B(NF-kappaB) on the expression of heme oxygenase-1 induced by lipopolysaccharide (LPS) in rats ' myocardium was obversed, and the effect exerted in endotoxic shock was explored
Kung et al., J Surg Res 2011 (Acute Lung Injury...) : LPS caused a significant HO-1 induction, whereas administration of EP 60 mg/kg significantly induced higher HO-1 expression compared with the LPS group
Gómez-Hurtado et al., Hepatology 2011 (Liver Cirrhosis...) : Unblocking IL-10 restored proinflammatory mediator and HO-1 expression to previously observed levels in response to LPS stimulation
Chung et al., J Cell Physiol 2012 (Inflammation) : While a great deal is known about the induction of HO-1 by inflammatory mediators and bacterial lipopolysaccharide (LPS) , much less is known about the effects of anti-inflammatory mediators on HO-1 expression ... Here we demonstrate that TGF-ß1 is able to downregulate LPS induced HO-1 in mouse macrophages, and this reduction in HO-1 occurred through signaling of TGF-ß1 via its type I receptor, and activation of Smad2
Leung et al., Toxicol Lett 2011 (Inflammation) : Our results demonstrated that in the presence of LPS , simvastatin significantly increased HO-1 expression and activity in a dose dependent manner compared to that of LPS stimulated alone macrophages
Dodd et al., Neurotoxicology 2011 : Manganese potentiates LPS induced heme-oxygenase 1 in microglia but not dopaminergic cells : role in controlling microglial hydrogen peroxide and inflammatory cytokine output ... Mn enhancement of LPS induced HO-1 does not appear to be dependent on H ( 2 ) O ( 2 ) or NO, as Mn+LPS induced H ( 2 ) O ( 2 ) release was not greater than the increase induced by Mn alone and inhibition of iNOS did not change Mn potentiation of HO-1 ... Finally, the potentiating effects of Mn on HO-1 appear to be glia-specific for Mn, LPS , or Mn+LPS did not induce HO-1 in N27 neuronal cells
Zhai et al., Inflammation 2013 (Inflammation) : Interestingly, DMPO increased anti-inflammatory heme oxygenase-1 (HO-1) expression and reversed LPS induced decrease in HO-1 expression
Chen et al., Food Chem Toxicol 2013 (Inflammation) : In summary, I. suffruticosa have a strong anti-inflammatory property that diminishes pro-inflammatory mediator expressions by lessening LPS induced NF-?B activation and inducing HO-1 expression in macrophages
Terazawa et al., Pharmacol Res 2013 : When treated with both, compound 1 enhanced LPS stimulated HO-1 induction, which was more evident at 24h after LPS treatment
Zhou et al., Biochem Biophys Res Commun 2013 (HIV Infections) : LPS activation of MDM markedly enhanced the expression of heme oxygenase-1 (HO-1) , a potent inducible cytoprotective enzyme
Camhi et al., Am J Respir Cell Mol Biol 1995 : We demonstrate that LPS induces high mRNA levels of the stress-inducible gene heme oxygenase-1 (HO-1) in the rat lung ... Transcriptional activation of the mouse HO-1 gene by LPS is mediated by a 5 ' distal enhancer fragment located approximately 4 kbp upstream from the transcription site
Rizzardini et al., Biochem J 1994 : It has been suggested that reactive oxygen and nitrogen intermediates are involved in hepatic toxicity of endotoxin ( lipopolysaccharide, LPS ) ; LPS even at low doses [ 0.1 mg/kg, intraperitoneally ( i.p. ) ] induces HO-1 mRNA about 25-fold after 1 h. Hepatic glutathione depletion ( respectively 40 % and 80 % ) after a low ( 0.3 g/kg ) or a high ( 1.6 g/kg ) BSO dose, resulted in potentiation of the HO-1 mRNA accumulation induced by LPS ( 0.1 mg/kg, i.p. ) ... In the absence of BSO, N-acetylcysteine (NAC) ( 1 g/kg orally ) reduced LPS induced HO-1 mRNA accumulation to one fourth ... Thus reactive oxygen intermediates are likely mediators of LPS induced HO-1 mRNA accumulation, and glutathione content appears to be one of the factors regulating this accumulation in the liver
Fujiwara et al., FEBS Lett 1996 : These compounds also prevented LPS stimulated heme oxygenase-1 (HO-1) and cyclooxygenase-2 (COX-2) gene expression in RAW264.7 cells, but again not in VSMC
Camhi et al., Am J Respir Cell Mol Biol 1998 : We have previously shown that lipopolysaccharide (LPS) induced HO-1 gene transcription in RAW 264.7 macrophage cells is mediated by a distal enhancer called SX2, located 4 kb upstream from the HO-1 transcription initiation site ( Am. J. Respir ... Here we report the extension of our studies to investigate whether the AB1 distal enhancer and/or other potential regulatory elements in the entire 5 ' distal flanking sequences ( 11-kb region ) of the HO-1 gene may also mediate HO-1 gene transcription in response to LPS ... Using deletional analysis, we found that the AB1 enhancer also mediates LPS induced HO-1 gene transcription ... Mutational analysis of the AB1 enhancer and electrophoretic-mobility-shift assays of nuclear extracts from LPS treated cells further demonstrated that the transcription factor activator protein-1 (AP-1) is critical for AB1 mediated HO-1 gene activation by LPS ... Taken together, these data suggest that LPS regulates HO-1 gene transcription in part by inducing the production of ROI, which initiate signal-transduction pathway ( s ) leading to the activation of AP-1 dependent HO-1 gene transcription
Rizzardini et al., Hepatology 1998 (Inflammation) : Gadolinium chloride and liposome encapsulated dichloromethylene diphosphonate lowered LPS mediated HO-1 mRNA accumulation ( by about 50 % ) ; in these groups hepatic levels of interleukin (IL)-1beta were decreased, by more than 75 % ... These results suggest that LPS mediated hepatic HO-1 mRNA accumulation is a hepatocyte response partly caused by soluble mediators, particularly IL-1beta, released from Kupffer cells
Kitamura et al., Life Sci 1998 : Immunocytochemistry showed that LPS-treatment induced iNOS-immunoreactivity predominantly in microglia, while this treatment induced HO-1-immunoreactivity in both microglia and astrocytes