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NCF1 — SRC
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
NCF1
→
SRC
(increases, SRC Activity, NCF1 Activity)
Touyz et al., Arterioscler Thromb Vasc Biol 2003*
Evidence: c-Src regulates NAD(P)H oxidase-derived *O2- generation acutely by stimulating p47phox phosphorylation and translocation and chronically by increasing protein content of gp91phox, p22phox, and p47phox in Ang II-stimulated cells
Text-mined interactions from Literome
Touyz et al., Arterioscler Thromb Vasc Biol 2003
:
c-Src induces phosphorylation and translocation of
p47phox : role in superoxide generation by angiotensin II in human vascular smooth muscle cells ...
c-Src regulates NAD ( P ) H oxidase derived *O2- generation acutely by stimulating
p47phox phosphorylation and translocation and chronically by increasing protein content of gp91phox, p22phox, and p47phox in Ang II-stimulated cells
Chowdhury et al., J Biol Chem 2005
:
Src mediated tyrosine phosphorylation of
p47phox in hyperoxia induced activation of NADPH oxidase and generation of reactive oxygen species in lung endothelial cells ... These results indicated that
Src dependent tyrosine phosphorylation of
p47(phox) regulates hyperoxia induced NADPH oxidase activation and ROS production in HPAECs
Usatyuk et al., J Biol Chem 2007
(Hyperoxia) :
Similarly, down-regulation of
Src with Src small interfering RNA attenuated the hyperoxia mediated phosphorylation of cortactin tyrosines and
blocked the association of cortactin with actin and
p47(phox)