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GRB2 — SRC

Pathways - manually collected, often from reviews:

• BioCarta links between pyk2 and map kinases: PYK2/SRC/GRB2/SOS-1 complex (PTK2B-SRC-GRB2-SOS1) → SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1) (modification, collaborate)
  
• BioCarta links between pyk2 and map kinases: PYK2/SRC/GRB2/SOS-1 complex (PTK2B-SRC-GRB2-SOS1) → SHC (SHC1) (modification, collaborate)
• BioCarta cbl mediated ligand-induced downregulation of egf receptors pathway: EGF R/SRC/EGF complex (EGFR-SRC-EGF) → GRB2 (protein ubiquitination, collaborate)
• BioCarta erk1/erk2 mapk signaling pathway: SRC → SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1) (modification, activates)
  
• BioCarta links between pyk2 and map kinases: SOS-1 (SOS1) → PYK2/SRC/GRB2/SOS-1 complex (PTK2B-SRC-GRB2-SOS1) (modification, collaborate)
  
• BioCarta links between pyk2 and map kinases: PYK2/SRC complex (PTK2B-SRC) → PYK2/SRC/GRB2/SOS-1 complex (PTK2B-SRC-GRB2-SOS1) (modification, collaborate)
  
• BioCarta links between pyk2 and map kinases: PYK2/SRC complex (PTK2B-SRC) → GRB2 (modification, collaborate)
• BioCarta links between pyk2 and map kinases: PYK2/SRC/GRB2/SOS-1 complex (PTK2B-SRC-GRB2-SOS1) → GRB2 (modification, collaborate)
• BioCarta calcium signaling by hbx of hepatitis b virus: PYK2/SRC complex (PTK2B-SRC) → SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1) (modification, activates)
  
• NCI Pathway Database Signaling events mediated by focal adhesion kinase: None → FAK/Src-Yes-Fyn/GRB2/SOS1 complex (PTK2-GRB2-SOS1-YES1_SRC_FYN) (modification, collaborate)
  Furuhjelm et al., J Cell Sci 2003, Schlaepfer et al., Nature 1994, Schlaepfer et al., Mol Cell Biol 1997, Schlaepfer et al., J Biol Chem 1997
  Evidence: mutant phenotype
• NCI Pathway Database Signaling events mediated by focal adhesion kinase: RRAS/GDP complex (RRAS) → FAK/Src-Yes-Fyn/GRB2/SOS1 complex (PTK2-GRB2-SOS1-YES1_SRC_FYN) (modification, collaborate)
  Furuhjelm et al., J Cell Sci 2003, Schlaepfer et al., Nature 1994, Schlaepfer et al., Mol Cell Biol 1997, Schlaepfer et al., J Biol Chem 1997
  Evidence: mutant phenotype
• NCI Pathway Database Plasma membrane estrogen receptor signaling: E2/ER alpha (dimer)/PELP1/Src/p52 SHC complex (ESR1-PELP1-SRC-SHC1) → E2/ER alpha (dimer)/PELP1/Src/p52 SHC/GRB2/SOS1 complex (ESR1-PELP1-SRC-SHC1-GRB2-SOS1) (modification, collaborate)
  Song et al., Mol Endocrinol 2002, Kumar et al., Mol Endocrinol 2007
  Evidence: physical interaction
• NCI Pathway Database Plasma membrane estrogen receptor signaling: E2/ER alpha (dimer)/PELP1/Src/p52 SHC complex (ESR1-PELP1-SRC-SHC1) → GRB2/SOS1 complex (GRB2-SOS1) (modification, collaborate)
  Song et al., Mol Endocrinol 2002, Kumar et al., Mol Endocrinol 2007
  Evidence: physical interaction
• NCI Pathway Database Plasma membrane estrogen receptor signaling: E2/ER alpha (dimer)/PELP1/Src/p52 SHC/GRB2/SOS1 complex (ESR1-PELP1-SRC-SHC1-GRB2-SOS1) → GRB2/SOS1 complex (GRB2-SOS1) (modification, collaborate)
  Song et al., Mol Endocrinol 2002, Kumar et al., Mol Endocrinol 2007
  Evidence: physical interaction
• NCI Pathway Database EPHB forward signaling: GRB2 (GRB2) → Ephrin B/EPHB1/Src complex (EFNB3_EFNB2_EFNB1-EPHB1-SRC) (modification, collaborate)
  Vindis et al., J Cell Biol 2003
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database EPHB forward signaling: GRB2 (GRB2) → Ephrin B/EPHB1/Src/p52 SHC/GRB2 complex (EFNB3_EFNB2_EFNB1-EPHB1-SRC-SHC1-GRB2) (modification, collaborate)
  Vindis et al., J Cell Biol 2003
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database EPHB forward signaling: Ephrin B/EPHB1/Src complex (EFNB3_EFNB2_EFNB1-EPHB1-SRC) → Ephrin B/EPHB1/Src/p52 SHC/GRB2 complex (EFNB3_EFNB2_EFNB1-EPHB1-SRC-SHC1-GRB2) (modification, collaborate)
  Vindis et al., J Cell Biol 2003
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database EPHB forward signaling: p52 SHC (SHC1) → Ephrin B/EPHB1/Src/p52 SHC/GRB2 complex (EFNB3_EFNB2_EFNB1-EPHB1-SRC-SHC1-GRB2) (modification, collaborate)
  Vindis et al., J Cell Biol 2003
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Signaling events mediated by focal adhesion kinase: FAK/Src-Yes-Fyn/GRB2/SOS1 complex (PTK2-GRB2-SOS1-YES1_SRC_FYN) → FAK/Src-Yes-Fyn complex (PTK2-YES1_SRC_FYN) (modification, collaborate)
  Shen et al., FEBS Lett 2001, Schlaepfer et al., Nature 1994, Schlaepfer et al., Mol Cell Biol 1996, Schlaepfer et al., Mol Cell Biol 1997, Schlaepfer et al., J Biol Chem 1997, Li et al., J Biol Chem 1997, Schlaepfer et al., Mol Cell Biol 1998
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Signaling events mediated by focal adhesion kinase: FAK/Src-Yes-Fyn/GRB2/SOS1 complex (PTK2-GRB2-SOS1-YES1_SRC_FYN) → GRB2/SOS1 complex (GRB2-SOS1) (modification, collaborate)
  Shen et al., FEBS Lett 2001, Schlaepfer et al., Nature 1994, Schlaepfer et al., Mol Cell Biol 1996, Schlaepfer et al., Mol Cell Biol 1997, Schlaepfer et al., J Biol Chem 1997, Li et al., J Biol Chem 1997, Schlaepfer et al., Mol Cell Biol 1998
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Signaling events mediated by focal adhesion kinase: FAK/Src-Yes-Fyn complex (PTK2-YES1_SRC_FYN) → GRB2/SOS1 complex (GRB2-SOS1) (modification, collaborate)
  Shen et al., FEBS Lett 2001, Schlaepfer et al., Nature 1994, Schlaepfer et al., Mol Cell Biol 1996, Schlaepfer et al., Mol Cell Biol 1997, Schlaepfer et al., J Biol Chem 1997, Li et al., J Biol Chem 1997, Schlaepfer et al., Mol Cell Biol 1998
  Evidence: mutant phenotype, physical interaction
• Reactome Reaction: GRB2 → SRC (indirect_complex) Lennartsson et al., Oncogene 1999, Nicholson et al., EMBO J 2001*, Arold et al., Structure 2002, Tauchi et al., J Biol Chem 1994, Schlaepfer et al., Nature 1994, Schlaepfer et al., Mol Cell Biol 1998
• Reactome Reaction: GRB2 → SRC (reaction) Lennartsson et al., Oncogene 1999, Nicholson et al., EMBO J 2001*, Arold et al., Structure 2002, Montagner et al., J Biol Chem 2005, Tauchi et al., J Biol Chem 1994, Schlaepfer et al., Nature 1994, Schlaepfer et al., Mol Cell Biol 1998

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: SRC — GRB2 (physical association, affinity chromatography technology) Wan et al., J Biol Chem 2003*
• IRef Biogrid Interaction: SRC — GRB2 (physical association, affinity chromatography technology) Saci et al., Biochem J 2002*
• IRef Hprd Interaction: Complex of 19 proteins (in vivo) Schulze et al., Molecular systems biology 2005
• IRef Hprd Interaction: SRC — GRB2 (in vivo) Saci et al., Biochem J 2002*, Jones et al., Arch Biochem Biophys 1997*
• IRef Hprd Interaction: SRC — GRB2 (in vitro) Saci et al., Biochem J 2002*, Jones et al., Arch Biochem Biophys 1997*
• IRef Ophid Interaction: SRC — GRB2 (aggregation, confirmational text mining) Saci et al., Biochem J 2002*
• IRef Ophid Interaction: SRC — GRB2 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Blaukat et al., J Biol Chem 1999 : Pyk2 induced activation of Src is necessary for phosphorylation of Shc and p130Cas and their association with Grb2 and Crk, respectively, and for the activation of ERK and JNK cascades
Park et al., J Immunol 1999 : The Src family tyrosine kinase inhibitor, PP1, was shown to completely inhibit Shc tyrosine phosphorylation, the Shc-Grb2 interaction, and the FcgammaR induced respiratory burst
Reiske et al., FEBS Lett 2000 : Finally, we provide evidence that the Src dependent association of FAK with Grb2 and p130 ( Cas ) are both required for the regulation of cell cycle progression by FAK
Faisal et al., J Biol Chem 2004 : In a quest for molecules upstream of ShcA in this signaling, we found that CSR induced ShcA tyrosine phosphorylation, its association with Grb2 , Erk activation, and uPA gene expression were all dependent on Rho kinase, p38 mitogen activated protein kinase, and Src
Li et al., Am J Physiol Cell Physiol 2007 (MAP Kinase Signaling System) : ANG II induced a Src dependent association between Shc and growth factor receptor bound protein 2 ( Grb2 ) and between Grb2 and son of sevenless ( Sos ), both of which were maximal at 15 min
Oikawa et al., J Cell Biol 2008 : The adaptor protein Tks5/FISH, which is essential for podosome formation, was found to form a complex with Grb2 at adhesion sites in an Src dependent manner
Samoylenko et al., Carcinogenesis 2012 (Adenocarcinoma...) : Thereby, Ruk ( l ) /CIN85 led to a more rapid and prolonged epidermal growth factor dependent activation of Src , Akt and ERK1/2 and treatment with the Src inhibitor PP2 and the PI3K inhibitor LY294002 abolished the Ruk ( l ) /CIN85 dependent changes in cell motility
Sieg et al., EMBO J 1998 : Significantly, repression of endogenous Src-family PTK activity by p50 ( csk ) overexpression inhibited FN-stimulated cell spreading, Pyk2 tyrosine phosphorylation, Grb2 binding to Shc, and ERK2 activation in the FAK- but not in FAK+ cells