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CCKBR — SRC
Text-mined interactions from Literome
Olszewska-Pazdrak et al., J Biol Chem 2004
(Colorectal Neoplasms...) :
Agonist binding to the cholecystokinin-2 (CCK2)/gastrin receptor (
CCK2R ), a G-protein coupled receptor,
increases Src activity in a variety of normal and neoplastic cell lines
Ferrand et al., World J Gastroenterol 2006
(Cell Transformation, Neoplastic...) :
We showed in vivo that the targeted
CCK2R expression in the pancreas of Elas-CCK2 mice,
led to the activation of
Src and the ERK pathway ...
Src was
activated upstream of the ERK pathway by the
CCK2R in pancreatic tumoral cells and contributed to the proliferative effects mediated by this receptor