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NCOA3 — TP53
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Amano et al., J Neurooncol 2009
(Brain Neoplasms...) :
Mechanistically,
Ad-p53 was capable only of
increasing the expression of
p21/CIP , whereas Ad-p53-15D20D increased the binding to and expression of the pro-apoptotic genes Fas, Puma and PIG3
Burger et al., Br J Cancer 1998
(Germinoma...) :
Consistently, the increase in wild-type
p53 protein in NT2 and 2102 EP cells
led to an increase in mRNA level of the p53 downstream gene
p21/WAF/CIP , whereas mutant p53 containing NCCIT cells and p53-non expressing S2 cells could not transactivate this p53-responsive gene
Liang et al., J Biol Chem 1998
:
In SAOS-2 cells, the mutant
p53 was a less efficient
inducer of
p21/CIP1/WAF1 expression
Li et al., Cancer Res 1998
(Leukemia, Myeloid, Acute) :
In contrast, induction of differentiation but not of proliferation was followed by a 25- to 30-fold increase in the nuclear level of the tumor suppressor proteins p53 ( wild type ), pRb, and p130/Rb2 and of the
p53 dependent cyclin kinase inhibitor
p21/Cip1