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RELA — RHO
Text-mined interactions from Literome
Reyes-Reyes et al., J Cell Sci 2001
(Leukemia) :
In addition, a dominant negative form of
Rho augmented
NF-kappaB activation and blocked MAPK activation, implying that these two pathways are in competition with each other
Cammarano et al., J Biol Chem 2001
:
Here we show that although Dbl activation of
NF kappa B requires Cdc42, Rac, and
Rho , the different GTPases activate NF kappa B by different mechanisms ... Whereas Rac stimulates the activity of the I kappa B kinase IKK beta, Cdc42 and
Rho activate
NF kappa B without activating either IKK alpha or IKK beta
Hippenstiel et al., Biochem Pharmacol 2002
:
In order to analyze the
role of
Rho proteins in TNF-alpha induced
NF-kappaB-activation in human umbilical cord vein endothelial cells ( HUVEC ) we used Clostridium difficile toxin B-10463 ( TcdB-10463 ) which inactivates RhoA/Rac1/Cdc42 by glucosylation and Clostridium botulinum C3-toxin which inhibits RhoA/B/C by ADP-ribosylation ... Blocking of
Rho reduced
NF-kappaB DNA binding as shown by electrophoretic mobility shift assays ... Therefore, TNF-alpha related Ikappa-B-degradation is Rho independent in HUVEC, whereas a Rho protein dependent signal is necessary to induce nuclear transport of NF-kappaB in these cells pointing to a novel and unique
role of
Rho in
NF-kappaB-translocation
Grassl et al., Cell Microbiol 2003
(MAP Kinase Signaling System) :
Using Clostridium difficile toxins that specifically inactivate small GTPases, and transfection of inhibitory proteins of the Rho-GTPases, we demonstrate that Rac1, but not Cdc42 or
Rho , is
required for activation of
NF-kappaB by invasin
Liu et al., J Biomed Sci 2004
(Adenocarcinoma...) :
We conclude that
Rho/RTKN mediated
NF-kappaB activation leading to cell survival may play a key role in gastric tumorigenesis
Liu et al., Oncogene 2004
:
Rho/Rhotekin mediated
NF-kappaB activation confers resistance to apoptosis
Morigi et al., Am J Pathol 2005
(Chronic Disease...) :
These data suggest that reorganization of the actin cytoskeletal network in response to protein load is implicated in modulation of the ET-1 gene via
Rho kinase
dependent FAK activation of
NF-kappaB and Ap-1 in differentiated podocytes
Wei et al., Mol Pharmacol 2006
:
Further studies showed that LPS down-regulated Rho and ROCK activity, whereas IL-1beta increased them, suggesting a negative
role of
Rho and ROCK signaling, which is regulated in contrary manners by IL-1beta and LPS, in
IKK/NF-kappaB activation
Iwasaki et al., Atherosclerosis 2008
(Hyperglycemia) :
High glucose induces plasminogen activator inhibitor-1 expression through
Rho/Rho-kinase mediated
NF-kappaB activation in bovine aortic endothelial cells
Meyer-Schwesinger et al., American journal of physiology. Renal physiology 2009
(Nephritis...) :
We therefore examined NF-kappaB signal transduction and found that
NF-kappaB p65 phosphorylation and nuclear translocation were
reduced by
Rho kinase inhibition
Perona et al., Genes Dev 1997
:
In contrast, activation of
NF-kappaB by UV light was not
affected by
Rho , CDC42, or Rac-1 dominant negative mutants