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BMP2 — NKX2-5

Text-mined interactions from Literome

Jamali et al., FEBS Lett 2001 : BMP signaling regulates Nkx2-5 activity during cardiomyogenesis ... Therefore, BMP signaling is necessary and sufficient for the regulation of Nkx2-5 activity during cardiomyogenesis in P19 cells
Prall et al., Cell 2007 (Heart Defects, Congenital) : We now show that feedback repression of Bmp2/Smad1 signaling by Nkx2-5 critically regulates SHF proliferation and outflow tract ( OFT ) morphology
Klaus et al., Proc Natl Acad Sci U S A 2012 (Wnt Signaling Pathway) : Using FACS enrichment of cardiac progenitors in RBPJ and RBPJ/Axin2 mutants, embryo cultures in the presence of the Bmp inhibitor Noggin, and by crossing a Bmp4 mutation into the RBPJ/Axin2 mutant background, we show that Wnt and Bmp4 signaling activate specific and nonoverlapping cardiac-specific genes in the cardiac progenitors : Nkx2-5 , Isl1 and Baf60c are controlled by Wnt/ß-catenin, and Gata4, SRF, and Mef2c are controlled by Bmp signaling